Computational Theoretical Chemist III

We are the only AI-native biotech, pioneering small and large molecule therapeutics discovery by integrating massive multimodal data, frontier AI models, and high-throughput lab automation into an infrastructure for AI-enabled drug discovery. 

We hire top 1% talent to join our interdisciplinary team of scientists, engineers, researchers, operators, innovators, drug developers, business professionals, and technologists.  

Join us to build the world’s first AI infrastructure for tech-enabled drug discovery and to deliver a pipeline of diverse drug modalities for all major disease areas. 

Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 , we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, data science, and software engineering to develop drugs for previously undruggable targets. 

• Own computational chemistry programs across therapeutic modalities, disease targets, and indications 

• Ensure effective collaboration with the Biology and Medicinal Chemistry teams by providing key computational chemistry insights to aid in the Hit-to-Lead and Lead Optimization phases of drug discovery operations  

• Ensure effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery as well as the incorporation of those models into drug discovery operations 

• Teach key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology 

• Manage day-to-day operations of the Computational Theoretical Chemistry Team, mentor junior staff, and represent the team in senior leadership meetings 

• Partner to improve 1910’s existing process for progressing from computational hit to experimental hit to lead to drug candidate 

• Co-author provisional patents and peer-reviewed research papers 

• Progress a virtual hit to a biochemical/cellular hit 

• Validate a cellular hit in a clinically relevant animal model of disease 

• Update provisional patents with the animal model data 

• Nominate a lead candidate for progression into IND-enabling studies 

• Attend and present research at conferences and events related to computational modeling in drug discovery 

• Publications in computational chemistry related to drug discovery 

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At 1910, we believe that a diverse, equitable, and inclusive workplace furthers relevance, resilience, and longevity. We encourage people from all backgrounds, ages, abilities, and experiences to apply. 1910 is proud to be an equal-opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status. If, due to a disability, you need an accommodation during any part of the interview process, please let your recruiter know. While 1910 supports visa sponsorship, sponsorship opportunities may be limited to certain roles and skills.