Scientist II - Molecular and Proteomic Immunology

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The mission of the Allen Institute for Immunology is to advance the fundamental understanding of human immunology through the study of immune health and diseases where excessive or impaired immune responses drive pathological processes. The Institute will employ a multi-disciplinary team approach in collaboration with academic centers of human immunology to generate novel mechanistic insights into the immune synapse in health and in diseases such as autoimmunity or oncology. The Institute will simultaneously provide a foundational data set and tools for future immunological research as well as a novel collaboration portal for the broader scientific community.

The Allen Institute for Immunology is looking for an exceptional molecular immunologist (Scientist II) to join a team focused on using and developing molecular and/or proteomic approaches to comprehensively study the interactions of the immune system. Specific responsibilities will include the design and development of new assays, technologies, and in vitro and ex vivo immunologic studies along with the analysis and synthesis of data generated through our cellular, molecular and proteomic platforms or their derivatives. A flexible and creative mindset along with the ability to function in a team to bring projects to completion on a timeline is essential.

The successful candidate will have a strong background in molecular and/or proteomic methodologies along with prior neuroscience and/or immunology experience. Strongest consideration will be given to candidates with a proven track record in identifying and progressing novel hypotheses forward in discovery research and technology development. This position is expected to last through December 2028 based on business needs and funding.

At the Allen Institute, we believe that science is for everyone – and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly.

We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.

We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

• Support the development and application of molecular and proteomic technologies to drive biological insight in the context of immunology. Examples include spatial and droplet based NGS platforms such as Xenium and 10x FLEX or REFLEX
• Development of cellular engineering approaches for dissecting immune function. Examples could include molecular recorder systems and high throughput screens
• Design, execute and analyze in vitro and ex vivo immunological studies utilizing cell lines, primary cells, and tissues to develop and test hypothesis, possibly including the utilization of genetic mouse models
• Collaboration with a team to bring projects to completion on a timeline

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

• Ph.D. or equivalent combination of degree and experience in a life sciences discipline
• 3+ years of postdoctoral experience

• A strong background in molecular biology including NGS platforms
• Experience in cellular immunology
• Direct experience with advanced approaches in deconstructing immunologic mechanisms & testing hypotheses (e.g. targeted mutagenesis using CRISPR/Cas9, phenotypic screening, antibody-based immune modulation, lentiviral work, cell culture, etc.)
• Proven success in troubleshooting and innovation on existing platforms, including publications and/or patents
• Demonstrated ability to independently analyze data through coding languages (R, python, bash, version control)
• Exceptional oral and written communication skills and ability to effectively present complicated concepts internally and externally in a cross-discipline environment

• Working in a laboratory environment with potential exposure to lasers, biohazards

• Occasional lifting to 30 pounds
• Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment
• Stooping, bending, crouching

• May need to work outside of standard working hours at times
• This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with flexibility to work remotely on a limited basis. We are a Washington State employer; any remote work must be performed in Washington State.
• This position is expected to last through December 2028, based on business needs and funding

• All employees who work with live animals must complete an Occupational Health medical history form and/or consultation with an Occupational Health Provider and receive clearance to work with animals. Depending on your health history and job responsibilities, an annual respiratory health screening and clearance to use a respirator may also be required.

• **Please note, this opportunity may offer work visa sponsorship**
• **Please note, this opportunity may offer relocation assistance**

• $105,600 - $130,650 *

* Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable.