US Medical Director, Health System & Payer Engagement

Position Summary The US Medical Director, Health System & Payer Engagement is a strategic in-house Medical Affairs role responsible for leading end-to-end scientific resource and engagement enablement across Health System and Payer MOSL teams. In close partnership with Medical Affairs Teams, SAM, VESt, Market Access, and cross-functional leadership, this role drives development of field-facing scientific, outcomes, and value-based resources to support effective engagement with health system decision-makers, payer stakeholders, C-suite healthcare leaders, clinical pharmacists, and other stakeholders influencing formulary and access decisions. This is a hybrid role with regular onsite presence expected in Cambridge, MA or Philadelphia, PA. Key Responsibilities * Lead US health system and payer medical engagement strategy across the TTR portfolio, including MOSL-focused scientific engagement, field enablement, and resource planning. * Develop, support training, and maintain insight-driven, field-facing scientific, outcomes, and educational resources aligned to evolving clinical, payer, health system, and evidence generation needs. * Partner cross-functionally with VESt, SAM, HEOR, Market Access, Scientific Communications, Field Medical, and US Medical leadership to align evidence generation, field execution, and health system engagement strategies. * Provide medical and scientific leadership for advisory boards, expert engagements, and relevant MOSL congress activities, including scientific content strategy and field support. * Serve as US Medical lead for MRL review and approval of MOSL field medical resources, ensuring scientific accuracy, strategic consistency, clinical relevance, and compliance. * Analyze field insights and stakeholder feedback to identify educational gaps, evidence needs, and opportunities to improve scalability, consistency, and operational effectiveness across field engagement tools and platforms. * Support integration of in-house medical strategy with field execution and access objectives in collaboration with MOSL leadership, National Accounts, and Market Access. * Apply strong strategic and business acumen to prioritize engagement opportunities, identify evidence gaps relevant to access decision-makers, and contribute to broader US Medical Affairs strategy and operational excellence initiatives. * Serve as a thought partner to senior medical leadership on evolving health system engagement models and innovative approaches to scientific exchange and field medical enablement. Qualifications Required * Advanced scientific or clinical degree required (PharmD, PhD, MD, DO, NP, or PA). * 5+ years of Medical Affairs experience, including significant experience supporting field medical & health system engagement initiatives. * Demonstrated experience leading cross-functional medical initiatives within matrix organizations. * Strong understanding of Field medical strategy and operations, MRL review processes and medical compliance, Scientific engagement and evidence communication, Health systems and payer dynamics * Strong strategic thinking, prioritization, communication, and stakeholder influence skills. Preferred * Experience supporting MOSL or health system engagement models. * Familiarity with integrated delivery networks, COEs, and evolving healthcare delivery models. * Experience within cardiovascular or related specialty therapeutic areas. * Experience supporting launch or growth-stage brands in competitive environments. #LI-JB1 U.S. Pay Range $238,800.00 - $323,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.