General Supervisor

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

We are looking for a driven General Supervisor (with California Clinical Laboratory Scientist License) to support UNITY, the only non-invasive prenatal test (NIPT) that can detect inherited disorders such as sickle cell disease, spinal muscular atrophy, and cystic fibrosis in the baby directly from maternal blood. These disorders are extremely severe, but early detection and intervention can significantly improve outcomes. You will lead and oversee our growing superstar CLIA team responsible for pregnancy blood sample processing in a high complexity, high-growth CLIA setting. The General Supervisor is an onsite position and reports to the Director of Laboratory Operations.

• →Lead clinical laboratory daily supervision in alignment with company values and mission
• →Hold General Supervisor delegation and responsibilities including oversight and support of day-to-day operations (Pre-analytical and Analytical), scheduling, and troubleshooting
• →Manage CLIA direct reports including licensed and/or unlicensed staff (CLS, Clinical Laboratory Assistants)
• →Oversee continuous process improvement projects including reagent quality control, tech transfer, troubleshooting, training, and validations
• →Facilitate communication between laboratory teams and other departments or stakeholders
• →Participate in recruiting efforts and hiring to meet sample volume demands
• →Foster a collaborative team environment for continuous growth and building skillsets
• →Partial owner of and leading execution of company objectives and key results

• Bachelor's degree in the chemical, physical or biological sciences
• Current or previous supervisory experience that includes direct supervision of lab staff
• Minimum of 4-5 years of CLS experience in a clinical setting (molecular and/or high-complexity laboratory experience preferred)
• A current California Clinical Laboratory Scientist License that meets requirements for Testing Personnel under CLIA regulations (42 CFR, part 493) (ASCP, CGMBS or generalist license is required)
• Hands-on training and experience with manual molecular biology protocols, including DNA extraction, PCR, and automated liquid handlers
• Advanced knowledge of Google Docs, Word, Excel, basic statistics and familiarity with LIMS systems and Next-Generation Sequencing
• Excellent leadership, communication, and interpersonal skills
• Strong attention to detail and ability to work flexibly and well under given timeframes
• Self-starter and dynamic team player with excellent verbal and written skills

• Previous CLIA General Supervisor experience
• Start-up experience
• Knowledge of medical genetics
• Experience in a cell-free DNA setting

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.
Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne’s Fetal Cell Capture™ Technology.
Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com