Research Associate II

At Freenome, we are seeking a Research Associate II to help grow the Process Development team within Genomics Early Development. The ideal candidate will work to optimize next-generation sequencing (NGS) processes and develop new methodologies on our multiomics platform. This person will work cross-functionally with Research & Development, Automation, Computation Science, Quality, Regulatory, Laboratory Operations, and Program Management on the development, characterization, scale-up and transfer of complex methodologies, processes and assays to Operations. You are passionate about contributing to developing life-saving diagnostics through early cancer detection, and you will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer.

The role reports to the Senior Manager of Genomics Early Development. This role will be an onsite role based in our Brisbane, California headquarters.

• →Apply hands-on knowledge of molecular biology, nucleic-acid biochemistry and next generation sequencing to develop and optimize NGS based methods and processes.
• →Execute experiments to characterize and optimize NGS workflows, converting prototypes into high-throughput automated assays.
• →Participate in data analysis and visualizations to answer experimental questions and identify areas for workflow optimization.
• →Present findings at team meetings and prepare technical reports for internal and external stakeholders.
• →Collaborate with cross-functional teams to integrate process improvements into the overall diagnostic workflow.
• →Assist with generating Standard Operating Procedures and Work Instructions with Laboratory Operations and Clinical Laboratory for transfer.
• →Support troubleshooting workflow issues, perform root-cause determinant experiments and propose effective data-driven solutions.
• →Maintain detailed records of experiments, data, results and methodologies in compliance with Good Laboratory and Documentation Practices (cGLP, cGDP).

• Bachelor’s or Master’s in Molecular Biology, Genetics, Biochemistry, or a related field with 2+ years of relevant industry experience.
• Hands-on experience in NGS based techniques, including nucleic acid extraction, library preparation, and sequencing.
• Experience with handling plasma and cfDNA in NGS workflows with low-volume, plate-based assay formats.
• Effectively communicates with team and cross-functional partners.
• High attention to detail - record and document accurate, objective observations, assess impact, and perform troubleshooting as needed.
• Excellent problem-solving skills, proactively looks for potential roadblocks, characterizes root causes to problems and collaborates with appropriate stakeholders.
• Ability to work independently as well as part of a cross-functional team.
• Flexible and adaptable to change and embrace a fluid work environment.

• Familiarity in a common scientific programming language (e.g., Python, R) is desirable.