Director, Toxicology

United States·Bothellexecutive

OtherDirector

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Overview

Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies.

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OtherDirector

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been submitted to the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-3050, an IND-cleared FAP-targeted radiotherapy; and IM-1617, an IND-cleared solid tumor ADC. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Director, Toxicology provides scientific and strategic leadership for the nonclinical safety assessment of oncology therapeutics from discovery through commercialization. This individual serves as the toxicology lead on multidisciplinary project teams and is responsible for developing scientifically rigorous, phase-appropriate nonclinical safety strategies that enable efficient progression of pipeline assets while meeting global regulatory expectations.

The Director partners closely with Research, Clinical Development, Translational Science (DMPK, Biomarkers), Regulatory Affairs, CMC, Biometrics, Pathology, and external CROs to design and execute toxicology programs supporting INDs, CTAs, BLAs, NDAs, lifecycle management activities, and responses to health authorities. The successful candidate combines deep scientific expertise with strategic judgment to identify and mitigate development risks while advancing innovative oncology therapeutics.

Responsibilities