Project Team Lead

San DiegoFull-Timelead

OtherManagementTeam LeadProject

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OtherManagementTeam LeadProject

Janux Therapeutics is seeking a Project Team Leader (PTL) to provide visionary leadership and strategic direction for the development and execution of Integrated Asset Plans across our oncology and autoimmune portfolio. The PTL will serve as the single point of accountability for the seamless delivery of project milestones and outcomes for one or more assets, guiding them from First-in-Human/First-in-Patient (FIH/FIP) studies through Phase 1–3 clinical development and comprehensive life-cycle management.

This role requires a leader with exceptional expertise in oncology drug development, a proven ability to drive cross-functional teams, optimizing team alignment, governance, and overall team health. The PTL will be entrusted with critical oversight of asset budgets, investment recommendations, and continuous optimization of asset strategies, ensuring alignment with Janux’s broader portfolio objectives.

Architect and execute comprehensive lifecycle strategies and franchise plans that maximize the value of each asset for patients, physicians, payors, and Janux as an organization.

Ensure alignment with corporate objectives and deliver sustained impact across the portfolio.

Lead or co-lead asset-based development partnerships and alliances, leveraging external and internal expertise to accelerate innovation and achieve program goals.

Create and communicate a compelling vision for designing, conducting, and executing innovative clinical development plans.

Develop and contribute to overall strategy for specific diseases/indications, ensuring a franchise-wide portfolio perspective.

Provide strategic insights and recommendations to optimize clinical development plans.

Anticipate and proactively address challenges across the development continuum, including risk assessment, mitigation planning, and adaptation to evolving regulatory and competitive landscapes.

Collaborate closely with Clinical Development, Regulatory Strategy, and Clinical Operations to deliver high-quality drug approval applications, ensuring successful regulatory outcomes and market access.

Collaborate with cross-functional teams to continuously refine clinical strategies, leveraging translational science, real-world evidence, and stakeholder feedback to optimize program outcomes.

Lead and develop a cross functional Asset Team comprised of Clinical Development, Statistics, Clinical Pharmacology, Translational Oncology, Regulatory, Commercial Development, Safety, Project Management, Operations, Pharmaceutical Sciences and other functions as determined by the organization’s needs.

Foster an effective, ethical, and inclusive culture that encourages teamwork, peer review, cooperation, and continuous improvement.

Champion diversity of thought, accountability, integrity, and process excellence.

Oversee team budget and headcount, ensuring optimal resource allocation.

Collaborate closely with leaders in Research, Development, Regulatory, and other key functional areas.

Build and maintain relationships with external leaders, physicians, and patient advocacy groups.

Be recognized internally and externally as an expert in the field, representing the organization at speaking engagements and industry forums.

Perform other duties as assigned.

PhD, PharmD, MD, or other advanced degree preferred.

10+ years of extensive clinical trial, drug development, and regulatory experience, with a strong scientific background.

Demonstrated ability to lead through influence, managing project teams in a matrix environment rather than direct line management.

Significant clinical development experience and exposure to different therapeutic modalities. Oncology and autoimmune experience are highly desirable.