Senior/Executive Director, Clinical Pharmacology Lead

United States·San DiegoFull-Timesenior

OtherHealthcareExecutive Director

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OtherHealthcareExecutive Director

Janux Therapeutics is seeking a hands-on, execution-driven Head of Clinical Pharmacology to support the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific contributor who thrives on working directly with data, ensuring high-quality PK analysis, and enabling data-informed decisions for dose selection and regulatory filings.

This position is focused on executional excellence and strategy. The key will be producing internal strategic alignment and scientific rigor in deliverables.

Serve as both the Head of Clinical Pharmacology and Clinical Pharmacology SME/Lead across multiple programs, on both the oncology and immunology side, setting and owning the execution of clinical pharmacology plans from IND through early clinical development (POC).

Design and oversee PK, PD, and exposure-response analyses to support dose selection, study design, and benefit-risk assessments.

Propose and lead the development and execution of clinical pharmacology components of studies, including food effect, drug-drug interaction, organ impairment, and QT assessments.

Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and support regulatory interactions.

Collaborate with Translational Medicine and Biomarker teams to integrate mechanistic and biomarker data into PK/PD interpretation.

Work closely with Biometrics and external modeling partners to support population PK and exposure-response modeling.

Contribute to program-level planning and prioritization based on pharmacological insights and development risk.

M.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field.

12+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry.

Direct experience designing and executing early-phase clinical studies, including healthy volunteer studies.

Strong expertise in PK analysis and exposure-response interpretation; experience in oncology or immnology preferred.

Experience managing external Clinical Pharmacology resources.

Proven track record of contributing to regulatory submissions and engaging with health authorities.

Excellent communication, collaboration, and organizational skills.

Ability to work independently and in a fast-paced, matrixed environment.