Kcasbio14d ago

Scientist II - Mass Spec Development (LC-MS/MS)

Kansas CityRegular - Full Timemid

OtherDevelopment

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Overview

Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Scientists at KCAS Bio get to do every day.

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Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Scientists at KCAS Bio get to do every day. If that gets you excited too, then maybe working as a Scientist at KCAS Bio is the role for you.

When you work as a Scientist II in the Mass Spec Bioanalysis Development group at KCAS, you get to further our mission by leveraging your knowledge in bioanalytical and scientific principles to independently execute defined aspects of studies, from study setup through data generation, as well as support development activities. You will utilize your scientific foundation to assess data integrity and troubleshoot with limited oversight.

Our Mass Spec Bioanalysis Development team uses LCMS (Liquid Chromatography Mass Spectrometry) techniques to conduct sophisticated sample preparation to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.

Execute study activities including sample preparation (extractions, enrichments/affinity capture, digestions), LCMS analysis, and data processing with limited supervision

Support method development, qualification, and optimization activities

Troubleshoot technical issues and propose solutions with limited guidance

Analyze data and prepare summaries for senior scientists to aid in client updates

Ensure compliance of study activities with pertinent portions of study protocol, SOPs & regulatory requirements

Communicate study progress and risks to senior staff

Provide informal guidance to junior staff as needed

Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values

Bachelor’s or master’s in chemistry, Biochemistry or chemical/biochemical engineering, or related field with at least 2–4 years of experience with LC-MS/MS

Hands-on experience with bioanalytical sample preparation, quantitative LC-MS/MS, and chromatography

Experience supporting method development, qualification, and troubleshooting

Experience with small molecule analysis; proteins, peptides, or biomarkers experience preferred

Familiarity with reversed phase or HILIC chromatography and standard bioanalytical workflows

Experience working in a regulated environment (GLP/GxP) preferred