Senior Product Manager, Oncology

• Own and execute the product roadmap for future Signatera features and service components.
• Write clear requirements that balance clinical customer needs with lab throughput realities.
• Build data-backed business cases and financial models for equipment, automation, and operational improvements.
• Run the change control process end-to-end: root cause analysis, requirements, board review, hypercare, and close-out.
• Define quantitative product performance indicators, track operational datasets, and drive systematic process improvements across teams.
• Establish go/no-go criteria and hypercare metrics for new feature launches, maintaining ownership through exit criteria.
• Conduct VOC interviews, market research, and competitive intelligence to validate product features and fuel market growth.
• Partner with product marketing to define positioning, pricing, and technical launch collateral.
• Communicate vision, roadmap progress, and technical updates clearly to cross-functional stakeholders.

• Bachelor’s degree in life sciences, physical sciences, statistics, or engineering. Master’s or PhD preferred.
• Minimum 5 years of professional experience, including 2-3 years in product management, commercialization, or strategic consulting within diagnostics, medical devices, or oncology.
• Experience with products delivered as laboratory services strongly preferred.
• Demonstrated experience driving data-driven process improvements using operational data and VOC to eliminate failure modes across the sample lifecycle.
• Hands-on experience with quality systems (CAPA, nonconformance, change control) in a CLIA/CAP lab environment preferred.
• Experience with SQL, Snowflake, Statistical Process Control (SPC), or continuous improvement frameworks (Lean, Six Sigma) preferred.

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.