PostEra7mo ago

Lead Software Engineer, Platform

RemoteFull-timelead

OtherSoftware EngineerSoftware EngineeringLead Software Engineer

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Quick Summary

Overview

PostEra is building a modern, 21st-century biopharma. We use Proton, our AI platform for medicinal chemistry, to accelerate the discovery of new medicines for patients.

Key Responsibilities

Technical Leadership and Execution: Lead the architectural design and contribute to the development of scalable web applications and microservices.

Technical Tools

airflowawsdjangokubernetespostgresqlpythonapi-designci-cdcode-reviewdata-analysisetlmentoringmicroservicespeople-management

PostEra is building an AI-first biotech. We use Proton, our AI platform for medicinal chemistry, to accelerate the discovery of new medicines for patients. PostEra is advancing an internal pipeline focussed on Women’s Health and Fertility, and has used Proton to nominate multiple clinical candidates across PMOS and Fertility. PostEra also advances small molecule programs through partnerships with pharma. We've closed over $1B in AI partnerships including 4 multi-year agreements with Pfizer and Amgen. PostEra is also leading an antiviral drug discovery center for pandemic preparedness, funded by one of the largest grants in NIH history.

PostEra's Organizational Structure:

· We believe time spent navigating complex hierarchies in organizations is better invested in the pursuit of novel technology and scientific discoveries. As such, our organizational structure is intentionally minimalist.

· We promote a culture where individual achievement is celebrated through proportional compensation and internal recognition, including meaningful promotions.

· Ultimately, our collective focus is delivering cures to patients, which we believe needs a huge amount of cross-disciplinary collaboration, so we've fitted our organizational structure to serve that end.

Role Overview:

In this role, you will be helping PostEra deliver on its mission of getting therapies to patients by shaping systems design decisions around our drug discovery platform, Proton. Design focus areas include things like data architecture, microservice design, and patterns for running async compute-heavy ML jobs.

In addition, you will keep close to the codebase by helping build and improve the platform upon which our team delivers features. You will lead by example, championing best practices in software development and engineering culture, while also spearheading innovative projects that push the boundaries of drug discovery.

You will make well thought out decisions about system architecture, including API design, application boundaries, and microservice communication. These systems should support the Proton platform in its pursuit to trivially handle many concurrent drug discovery projects running in parallel at industry-leading speed. Your leadership style should foster an environment of learning and improvement within our engineering team in which you should strive to build technical rapport with colleagues through coding and code review.

We are looking for someone who was substantial experience designing, building, and operating production systems at scale, and who enjoys mentoring engineers through direct technical collaboration.

Key Responsibilities:

Technical Leadership and Execution: Lead the architectural design and contribute to the development of scalable web applications and microservices. Deep technical knowledge and professional experience:

· Using cloud providers (ideally AWS), container orchestration frameworks, and IaC best practices.

· Working with teams who ship products using web-dev stacks composed of Python, modern frontend frameworks, and relational databases like PostgreSQL.

Mentorship and Collaboration: Play a pivotal role in mentoring engineers, promoting a culture of cross-team collaboration and continuous learning. Candidate will:

· Be instrumental in facilitating knowledge sharing sessions, code reviews, and defining team-wide technical standards.

· Nurture the technical growth of our team members, while potentially managing a small team of direct reports, with the possibility of growing into a larger people leadership role.

Projects You May Lead:

Innovative Drug Discovery Projects: Collaborate with scientists and ML experts to tackle challenges directly contributing to the discovery of novel medicines. Specific challenges may include projects such as expanding molecular search to 100B+ scale, designing automated AI-medicinal-chemist workflows, bringing novel ML research to production, and creating tools for real-time data analysis in drug design processes.

Engineering Excellence Initiatives: Drive projects focused on enhancing our engineering framework such as architecting backend interactions with ML systems, improving our CI/CD processes, setting new standards for code quality and testing, incorporating AI tooling into our development processes, and implementing monitoring solutions that offer real-time insights into our applications' performance.

Key Requirements:

· 8+ years of professional software engineering experience and a bachelor's degree (or more advanced education) to succeed in this role

· Experience in systems design and backend web development

· Strong communication skills

· Experience with technical mentorship focus or people management responsibilities

Nice to Haves:

Candidate is more likely to succeed in this role if they also have:

· Expertise in a python based backend web framework (we use Django, for example)

· Experience integrating ML systems into production services/software

· Familiarity with container orchestration or workflow systems (like: Kubernetes, Kubeflow, Argo, Airflow)

· Have some familiarity with data pipelines

· Experience with designing agentic workflows/context engineering

Salary: 190k - 220k

Equity: 0.10% - 0.20%

Visa Sponsorship: Not at this time

Hiring Manager: Matt Robinson

Visit us at postera.ai

Location & Eligibility

Where is the job

Worldwide

Fully remote, anywhere in the world

Who can apply

Same as job location

Listed under

Worldwide

Listing Details

Posted: January 9, 2026
First seen: April 3, 2026
Last seen: August 22, 2026

Posting Health

Days active: 145
Repost count: 0
Trust Level: 32%
Scored at: August 26, 2026

Signal breakdown

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PostEra

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PostEra is building a modern 21st century biopharma. We’re using our advances in machine learning to close the Design-Make-Test cycle of Medicinal Chemistry and bring more cures to patients.

Employees

Founded

2019

Domain

Jobs

External application · ~5 min on PostEra's site

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