Co-op: LNP Process Development

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Prime Medicine is seeking a co-op for the Spring 2026 semester to work in a cross-functional LNP formulation and process development team. The candidate will work with formulation scientists, process development engineers, and chemical engineers to optimize mRNA and LNP formulation and processes related to the manufacture of LNPs. The candidate will gain hands-on experience with various LNP formulation techniques and processes, analytical and biophysical characterization, and play a critical role in solving challenging problems associated with LNP formulation and process development.    

We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.

• →Collaborate with the LNP formulation and process development team, and cross-functional teams to execute experiments supporting Prime Medicine goals
• →Execute experiments to optimize and understand the robustness of LNP formulations and related processes
• →Perform analytical testing for assessing LNP formulations and payload quality as it relates to critical process parameters
• →Effectively communicate results to internal and external meetings, and present the final summary to the team
• →Document and manage all experimental planning and progress in electronic lab notebook in an organized manner, providing statistical analysis and troubleshooting where appropriate.
• →Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies.

• B.S./M.S. candidate in Chemical Engineering, Chemistry, Bioengineering or Biochemistry
• Prior wet lab experience with processes and methods of making and testing LNPs is preferred.
• Prior Co-Op experience(s) is preferred.
• Knowledge of mixing techniques, tangential flow filtration, and characterization techniques (DLS, plate based assays, HPLC) for LNPs
• Familiarity with DOE is a plus
• Excellent written and verbal communication skills.
• Curious, ability to work independently or collaboratively as needed
• Self-motivated, detail-oriented with strong critical thinking skills and excel at identifying and solving problems.