Scientist, Hematopoiesis (iPSCs)

United States·Redwood CityFull-timemid

OtherScientist

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Overview

Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan.

Requirements Summary

Technical Tools

OtherScientist

We’re building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility.

We are hiring a new member of the HSC Therapeutics team who will bring deep expertise in hematopoiesis. In this role, you will focus on process optimization and development to help us create scalable differentiation protocols.

You’re eager to learn and approach work with a “can-do” attitude and a hands-on nature. You take pride in working at the highest standard, continuously optimizing research practices for both high speed and accuracy. You value being organized and detail-oriented. Bringing a clear, transparent communication style, you collaborate effectively with specialists of various backgrounds (bench and computational biologist, quality control scientists, operational and logistic specialists). You are adaptable and able to iterate quickly and reprioritize based on a mission > team > self hierarchy. You’re motivated to work on the forefront of science and help us extend healthy lifespan!

Adapt differentiation protocol to large-scale production in bioreactors and optimize banking of final product for clinical use.

Optimize differentiation process for reproducible and predictable cell output.

Contribute to the full process of producing a high-quality iHSC product out of iPSCs: maintain iPSCs, prepare and change media throughout differentiation, analyze cells using flow cytometry, and formulate iHSCs.

Transfer differentiation and formulation protocols to the GMP environment.

Assist in processing mouse tissues and performing flow cytometry to characterize cell function.

Work collaboratively across Retro teams such as Technical In-Vivo, Computational Biology, Automation, and Quality and Analytics.

Be part of a rotational weekend work schedule.

Have a Bachelor’s or Master’s degree in Biology or a relevant field and 4+ or 6+ years of relevant experience in industry, respectively, or a Ph.D. in Cell Biology, Molecular Biology, or related discipline.

Learn quickly and establish and follow protocols precisely.

Your deepest expertise is in hematopoiesis.

Have 2+ years of experience in differentiating iPSCs into immune cells.

Enjoy standardizing lab practices and establishing highly reproducible protocols.

Have 2+ years of experience with cell characterization using flow cytometry.

Have excellent note-taking skills and take pride in maintaining detailed ELN.

Proficient in designing and coordinating projects across multiple parties.

Proficient in communicating results of experiments.

Had exposure to the GMP environment and participated in IND filings.

Have experience with process development and scaling cell therapies in bioreactors.