structuretx
New
114,000-140,000/yr

Senior Payroll GL Accountant

United StatesUnited States·South San FranciscoFTEsenior
OtherGl Accountant
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Quick Summary

Key Responsibilities

Payroll Processing:-Own the end-to-end semi-monthly payroll process for U.S.-based employees via ADP TotalSource,

Requirements Summary

EducationBachelor's degree in Accounting, Finance, or Business Administration (with an accounting concentration) Experience-5+ years of relevant accounting experience,

Technical Tools
OtherGl Accountant

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions. Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.


Position Summary:
We’re looking for a Senior Payroll/GL Accountant with strong expertise in Payroll and General Ledger (GL) operations to join our Finance team. In this role, you'll take full ownership of the payroll process, act as the primary point of contact for payroll and payroll tax matters and help streamline accounting operations. The ideal candidate brings hands-on experience in ADP TotalSource and NetSuite, thrives in a fast-paced, high-growth environment, and is passionate about accuracy, compliance, and process excellence.


Job Responsibilities:

Payroll Processing:
-Own the end-to-end semi-monthly payroll process for U.S.-based employees via ADP TotalSource, and coordinate payroll for our EMEA employees with an international payroll provider
-Process off-cycle payroll, including taxable event reporting for equity transactions (e.g., RSU vesting, stock option exercises, ESPP)
-Monitor and resolve payroll tax issues, ensuring accurate withholding, reporting, and compliance across jurisdictions
-Strengthen internal controls surrounding the payroll process to maintain SOX compliance 


Journal Entries & Month-end Close:
-Prepare monthly payroll journal entries, including detailed department and time allocation, ensuring accurate payroll cost distribution across the organization
-Contribute to the monthly period-end close by reconciling payroll-related balance sheet accounts and verifying accuracy and completeness

Expense Review:
-Review employee expense report coding in Ramp prior to synchronization with NetSuite

Accounting Operations & Collaboration
-Partner with Finance and HR teams to support the payroll and monthly close process and implement efficiency and accuracy improvements
-Support general ledger tasks, such as preparing cash journal entries, bank account reconciliations, and others as needed
-Coordinate and provide PBC (Prepared by Client) documentation to external auditors in support of SOX testing, quarterly and annual financial audits


Qualifications:


Education
Bachelor's degree in Accounting, Finance, or Business Administration (with an accounting concentration)


Experience
-5+ years of relevant accounting experience, with direct payroll ownership preferred
-Hands-on experience with ADP TotalSource and NetSuite
-Strong knowledge of payroll tax regulations, including multi-state withholding, equity compensation taxation, and year-end reporting (e.g., W-2, 941s)
-Experience with Equity Edge Online and understanding of equity reporting and related payroll tax withholding and compliance requirements
-Proficient in US GAAP and payroll accounting principles; Proven experience supporting month-end close and account reconciliations
-Familiarity with SOX compliance
-Advanced Excel skills a must
-Highly organized, detail-oriented, and proactive in identifying process improvements
-Excellent communication skills and ability to collaborate cross-functionally


Travel Required:
This position is primarily based in the San Francisco Bay Area and requires little to no travel. Travel may be required on an occasional basis for meetings, training, or company events.


Structure Therapeutics Inc. is an Equal-Opportunity Employer. 
Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $114,000-$140,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.


At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance-based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.


Notice to Recruiters/Staffing Agencies
Recruiters and staffing agencies should not contact Structure Therapeutics through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees.
We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.
Structure Therapeutics’ receipt or acceptance of an unsolicited resume submitted by a vendor organization to this website or employee does not constitute an actual or implied contract between Structure Therapeutics and such organization and will be considered unsolicited and Structure Therapeutics will not be responsible for related fees.


Fraud Alert
To all candidates: your personal information and online safety are a top priority for us. At Structure Therapeutics, direct candidates to apply through our official career page at BambooHR.
Recruiters will always contact you using the domain of Structuretx.com. We will never request payments, ask for financial account information or sensitive information like social security numbers. If you are unsure if a message is from Structure Therapeutics, please email human resources.

Location & Eligibility

Where is the job
South San Francisco, United States
On-site at the office

Listing Details

Posted
June 25, 2026
First seen
June 25, 2026
Last seen
June 25, 2026

Posting Health

Days active
0
Repost count
0
Trust Level
63%
Scored at
June 25, 2026

Signal breakdown

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structuretxSenior Payroll GL Accountant114,000-140,000