Research Assistant

Summary

The Research Assistant will support research in the O'Connor-Giles Laboratory, which studies synapse formation, function, and plasticity in Drosophila melanogaster. The lab uses genetic, imaging, physiological, and behavioral tools in the fly model to identify and characterize conserved synaptic genes, with a focus on those associated with neurodevelopmental disorders.

The Research Assistant will focus on a current project PDZD8, a new signaling molecule the lab identified as a positive regulator of activity-dependent synaptogenesis. PDZD8 operates at signaling sites between organelles where the exchange of lipids, ions, and other metabolites regulates the formation of new synapses in response to neuronal activity. This work connects intracellular signaling at membrane contact sites to protein turnover in neurons and to nervous system development and has implications for how PDZD8 disruption causes intellectual disability in humans.

The Research Assistant will have four primary duties:

• Performing Drosophila brain dissection, immunohistochemistry and microscopy.
• Preparing Drosophila brain samples for proteomics studies, including analysis, visualization and interpretation of results.
• Molecular cloning to generate transgenes and CRISPR alleles for in vivo studies.
• Drosophila husbandry, maintenance and genetics.

The Research Assistant will also support the lab's broader research activities, including general lab maintenance and contributing to manuscript preparation.

This is a fixed-term position with an end date of one year from the date of hire, which may be extended depending on available funding.

Please review additional information on the Benefits of Working at Brown.

The designated Position Work Location for each position determines the approved modality of work. Positions are classified based on the operational and business needs of the department and may be designated as on-site, hybrid, or remote.

Employees with a designated position work location as remote must reside and perform their work in a state where Brown University is registered to do business. Brown University is a registered employer in the following states: Rhode Island, California, Colorado, Connecticut, Florida, Maryland, Massachusetts, New York, New Hampshire, New Jersey, North Carolina, Washington, D.C.

Please note that to be considered for a staff position at Brown University, you must submit a separate application for each position you wish to be considered for. Applications are reviewed only for the specific position to which they are submitted and are not automatically considered for future openings.  

This position is not eligible for visa sponsorship.

If you have any questions you may contact employment@brown.edu.

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