Senior Scientist, Medicinal Chemistry Discovery

Monte Rosa Therapeutics (MRT) seeks to recruit an enthusiastic, creative and highly talented medicinal chemist who is eager to discover molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable.

This position plays a key role in contributing to the development of our growing portfolio and will have a crucial impact at the forefront of drug discovery. The successful candidate should have strong interest in early-stage drug discovery, prior experience in HTS data analysis, hit follow-up as well as utilizing state-of-the-art medicinal chemistry knowledge.

• →Analyze High Throughput Screening (HTS) output with the goal of identifying promising starting points for hit generation chemistry from our growing MGD library.
• →Serve as a chemistry project lead against multiple early-stage projects across different disease area.
• →Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists.
• →Create structure activity relationship driven hypotheses for follow-up experiments to probe target engagement in hit validation.
• →Provide tool compounds and contribute to target validation efforts as member of a cross-functional discovery team.
• →Provide chemistry progressability assessments for early targets.
• →Familiarity with key concepts and optimization strategies in medicinal chemistry including a clear understanding of ADME properties.
• →Efficient and timely execution of compound syntheses through our CRO network, by devising efficient synthetic routes.
• →Collaborate with external research partners.
• →Communicate scientific findings and project updates to senior leadership and governance.
• →Summarize and publish findings in manuscripts and patents when appropriate.

• PhD in synthetic organic/medicinal chemistry with 5+ years of experience in pharmaceutical/biotech industry, or MS with 12+ years of experience is acceptable.
• Deep experience of High Throughput Screening analysis and follow-up.
• Familiarity with early stages of pre-clinical research in drug discovery.
• Experience of collaborating with CROs is essential.
• High level of proficiency with databases, data analysis and visualization tools (e.g. Spotfire, D360, CDD, Maestro, Pymol).
• Proficiency in complex molecule synthesis and/or synthetic method development experience.
• Proficiency in complex molecule synthesis and/or synthetic method development experience.
• Apply state-of-the-art medicinal chemistry design principles to MGD discovery
• Excellent teamwork skills and the ability to work effectively in global, cross-disciplinary drug discovery teams (biochemistry, biology, structural biology, CADD, and DMPK).
• Communicate scientific findings and project updates to senior leadership and governance.
• Excellent written and oral communication skills.