Associate Director, FP&A

United States·WalthamFull-timeexecutive

OtherAssociate

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Overview

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program,

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Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

We are seeking an Associate Director of FP&A to support corporate and program level planning, budgeting, and forecasting. This individual will partner closely with R&D, Program Management, Clinical, Tech Ops, and G&A teams to deliver high quality financial insights, support decision making, and ensure disciplined financial management in a dynamic, science-driven environment.

This role is ideal for someone who thrives in high growth biotech, can balance strategic thinking with hands on execution, and is excited to build scalable FP&A processes. Please note, this person must be local to the Waltham, MA office and have experience in the life sciences, biotech FP&A-space.

Own the FP&A function across the full early-stage oncology portfolio, spanning discovery research, preclinical development, IND-enabling programs, and Phase I/II clinical trials
Serve as a strategic finance partner to the Chief Scientific Officer, Head of Clinical Development, and SVP of Tech Ops, providing financial insight and decision support tied to asset progression and portfolio prioritization
Lead program-level and portfolio-level financial modeling, including cost-to-complete analyses, risk-adjusted NPV assessments, and scenario planning around key preclinical and early clinical inflection points such as IND filings, RP2D determinations, and preliminary efficacy signals
Oversee financial management of CDMO and CRO relationships supporting IND-enabling toxicology, drug substance/drug product manufacturing scale-up, and Phase I/II clinical execution, including governance of budgets, change orders, and milestone payment schedules
Drive the annual operating budget, mid-year reforecast and multi-year long-range plan, working cross-functionally with research, CMC, translational medicine, regulatory, and clinical teams to align financial projections with program timelines and go/no-go criteria
Develop and maintain capital runway models and cash burn analyses to support treasury planning, board reporting, and investor communications at a stage where capital efficiency is critical
Build and refine FP&A infrastructure including forecasting tools, program tracking systems, and reporting cadences suited to the pace and uncertainty of early-stage drug development
Present financial results, program spend analyses, and strategic scenarios to the leadership team
Partner with accounting colleagues to build financial discipline and cross-functional partnership skills appropriate for a fast-moving early-stage biotech environment
Support business development activities including in-licensing diligence, sponsored research agreement structuring, and collaboration deal modeling focused on early-stage oncology assets

Bachelor’s degree in Finance, Accounting, Economics, or related field.
8+ years of progressive FP&A experience within biotech or pharma space
Experience supporting R&D, clinical development, or other multiprogram environments
Experience with biotech planning cycles (e.g., program budgeting, CRO/CMO forecasting) preferred
Familiarity with ERP systems, planning tools, and business intelligence platforms (e.g., NetSuite, Adaptive Insights a plus)
Demonstrated ability to partner cross-functionally and communicate complex concepts clearly
Ability to manage competing priorities and operate in a fast-paced, high-growth environment
Highly analytical with strong attention to detail
Proactive problem solver who anticipates needs
Strong interpersonal skills and business judgment
Collaborative team player

Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment

Competitive compensation, including base salary, performance bonus, and equity

100% employer-paid benefits package

Flexible PTO; also, two, one-week company-wide shutdowns each year

A commitment to your professional development, with access to resources, mentorship, and growth opportunities

The salary range for this position is $180,000 to $210,000. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.

Additional Description for Pay Transparency:

The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation – Unlimited PTO; Sick time – 10 days per calendar year; Holiday pay, including two Company shut downs; Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA; Military Leave. Additional information can be found - https://www.crescentbiopharma.com/careers/#benefits