Senior Software Engineer

Natera is seeking a skilled, self-motivated, and hands-on Senior Software Engineer to join a software development team in the Oncology domain within a fast-growing biotech company. You will play a key role in building critical web applications and services alongside full-stack and UI engineers. System design is a core tenet of our engineering culture. You will drive technical excellence, mentor peers, and collaborate with product and design teams to deliver exceptional user experiences. Working closely with cross-functional stakeholders, you will develop scalable solutions while maintaining high standards for quality and compliance.

• →Directly contribute to engineering initiatives through hands-on coding, design, and architecture.
• →Navigate ambiguous problems and act as a self-starter, taking the initiative to communicate directly with product management and other stakeholders to define technical requirements, solutions, and timelines.
• →Drive technical roadmap execution and lead architectural decisions, upholding system design as a core tenet of all deliverables.
• →Participate in code reviews and foster a culture of code quality, testing, and documentation.
• →Establish and maintain engineering best practices and quality standards.
• →Balance technical debt with new feature development.
• →Mentor developers, seeking out opportunities and providing guidance for engineers to grow and excel.
• →Work with systems handling Protected Health Information (PHI) and sensitive data.
• →Complete HIPAA/PHI privacy and compliance training within 30 days and maintain current status on Natera training requirements.

• 8+ years of software engineering experience.
• Strong technical background in modern web development, specifically using React and JavaScript/TypeScript, including experience with complex embedding patterns (iframes, cross-origin messaging).
• Experience with programming in JavaScript frameworks such as NextJS.
• Solid understanding of backend systems, APIs, and databases (PostgreSQL, Snowflake, or similar).
• Experience with cloud infrastructure and providers, with AWS being preferred.
• Experience building LLM-powered applications — such as agentic pipelines, tool-calling systems, or AI-augmented workflows — is a strong plus.
• Strong understanding of software development methodologies and track record of successful project delivery.
• Experience in Healthcare IT or developing software in a regulated environment is a plus.

• Deep expertise in system design, building highly scalable distributed systems, and developing enterprise applications using JavaScript/TypeScript or similar modern web languages.
• Strong hands-on coding, design, and architecture skills.
• Demonstrate initiative as a self-starter with a proactive approach to navigating ambiguity, addressing complex issues, and finding creative solutions.
• Ability to thrive in a Cursor and Claude shop, effectively utilizing advanced AI tooling to augment development workflows and accelerate problem-solving.
• Excellent project management skills in Agile environments.
• Ability to collaborate cross-functionally and communicate effectively with peers and stakeholders.

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.