Bioinformatics Scientist (Remote)

United States·NatickRemoteFull timemid

Bioinformatics ScientistData & AI

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Quick Summary

Overview

Our bioinformatics team, working in biostatistics, genomics and bioinformatics in the next-generation sequencing (NGS) domain is expanding.

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Our bioinformatics team, working in biostatistics, genomics and bioinformatics in the next-generation sequencing (NGS) domain is expanding. We are searching for a bioinformatics data scientist to focus on design and improvement of PCR assays for high throughput NGS genomic sequencing. This exceptional opportunity offers the chance to work with a team focused on the forefront of genomic and cellular understanding of cancer.

Work closely with software, experimental, regulatory, biological and clinical collaborators as a key member of the bioinformatics team in understanding assay performance

Support the PCR primer/probe design. Identifies known and emerging nucleic acid biomarkers (SNV, InDel, DupDel, CNV, methylation, and fusions) via review of scientific papers and clinical trial summaries that drive treatment choices or are useful for monitor disease progression

Analyze and interpret high-throughput internal DNA and RNA sequencing data from designed chemistry, with a specific focus on mutation identification and oncology characterization

Improve biology/oncology understanding and assay performance based on the data.

MS with 3+ years of experience or PhD in genetics or related discipline

Passionate about bioinformatics and data science

Proven critical thinking capability with ability to follow through

Proven understanding of both human genetics, oncology, and the genetic variation associated with various types of cancer

Well versed with public sequence depositories of genome sequence and variation data, especially those focused on oncology and is able to query, retrieve, manipulate, and analyze data from these databases

Experienced with the development of nucleic acid diagnostics based on the amplification of DNA and RNA via PCR

Excellent communication (written and verbal) and data presentation skills.

Deep knowledge and experience analyzing NGS data on human genome, either from industry or academia

Proficiency with standard NGS tools like bwa, samtools, bedtools, etc.

Experience working with somatic or low input DNA assays

Experience and knowledge of commercially available of modern variant calling packages

Proficient with excel or scripting language to analyze/understand NGS data

Please note we are unable to provide sponsorship for this role including CPT, OPT, H-1B, O, or Green Card Support