Senior Scientist to Principal Scientist, In-vivo Biology

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

This position will play a key role in advancing the research pipeline and drug discovery projects.  Anchored in Discovery Unit, the successful candidate will be responsible for designing, overseeing and interpreting in vivo studies in obesity, metabolic disease and related disease areas.  The position will be an essential part of an interdisciplinary team, collaborating closely with cross-functional team members and contributing to project success. 

Job Responsibilities:

• Establish and coordinate in vivo studies and related analytical readouts.
• Lead biology and drive discovery project to progress and achieve milestones
• Design and execute in vivo pharmacology studies to support target validation and drug candidate discovery. Ensure that experiments are performed to a consistently high standard
• Manage out-sourced studies with CROs and/or academic collaborators
• Responsible for data review, analysis and interpretation to enable program go/no-go decisions
• Work with research teams to manage multiple projects
• Support team members
• Interpret and present scientific findings at internal and external research meetings
• Collaborate and communicate across a diverse research team to progress scientific goals

Qualifications:

• PhD in Biology or related field with at least 2 years of post-doctoral experience. Industrial experience is preferred
• Hands on experience in in vivo pharmacology and assays.
• Deep understanding of obesity and metabolic disease related physiology and pathology.
• Experience in working with translational teams a plus
• Experience in discovering and validating drug targets and in progressing molecules into lead optimization. Experience in driving projects towards IND is preferred
• Excellent verbal and written communication skills with an ability to organize and communicate complex data sets in a clear and concise manner
• Demonstrated ability to work effectively in cross-functional team.
• Prior experience working at fast-paced biotech is preferred

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, ongoing performance-based equity and various benefits offerings.