Scientist I, Platform Development and Antibody Screening

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

• Develop novel antibody screening technologies and experimental platforms, from early proof-of-concept through scalable, robust workflows
• Design, implement, and optimize screening assays, including biochemical, molecular, and cell-based readouts
• Assist multidisciplinary platform development efforts as a biochemical expert through microbial and mammalian cell line engineering (e.g. cloning, genome editing, expression optimization)
• Apply data-driven and critical thinking approaches to troubleshoot, refine, and improve workflows, enhancing throughput, robustness, and interpretability
• Clearly document experimental workflows, present results, and contribute to shared platform standards while maintaining flexibility for rapid exploration
• Collaborate closely with cross-functional partners (automation, engineering, computation) to integrate biology, data, and technology into cohesive systems

• PhD in Molecular Biology, Bioengineering, Biochemistry, or a related field with 1+ years of industry experience, or
  B.S. or M.S. with 8-10 years of relevant industry or applied research experience
• Prior work on platform, workflow, or method development, especially in exploratory or early-stage settings (see examples under Bonus Skills)
• Experience with antibody discovery and engineering workflows, including panning, enrichment, or display-based screening approaches
• Experience with assay development, optimization, and experimental troubleshooting
• Strong hands-on experience in molecular cloning and DNA manipulation
• Experience with cell-line engineering (e.g. E. coli, yeast, mammalian or related systems)
• Demonstrated ability to work independently, think critically, and drive conclusive experiments
• Strong organizational skills and attention to experimental detail

• Experience with functional antibody screening or protein–protein interaction assays
• Familiarity with high-throughput or semi-automated screening systems
• Experience working with data-rich experimental systems
• Comfort operating in fast-moving, collaborative, and partially undefined problem spaces

Experience in one or more of the following areas would be a plus:

• Spatial biology technologies (e.g. spatial transcriptomics, in situ or imaging-based assays)
• Single-cell technologies, including single-cell sequencing or high-content single-cell assays
• Microarray-based assays or other multiplexed screening formats
• Microfluidics, particularly for screening, assay miniaturization, or single-cell applications
• High-content imaging or phenotypic screening
• Experience studying or manipulating cell-internal signaling pathways (e.g. receptor signaling, transcriptional regulation, immune signaling, stress responses, or related pathways)
• Protein expression, secretion, or trafficking assays

Compensation: Annual

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity.  The base pay range for this position is expected to be $110,000 - $138,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.