Scientist, High-Throughput Biology

Overview We are seeking a highly motivated scientist to join our High Throughput In Vitro Screening team. This role will lead the in vitro screening workflow to generate high-quality, decision-enabling data across multiple programs. This is a hands-on, in-lab role. The candidate is expected to contribute at the bench, partnering with associates and scientists to execute and troubleshoot experiments. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities * Lead, mentor, and develop scientists to foster a high-performing, collaborative team * Drive end-to-end in vitro screening workflows, from assay development through data delivery, to enable timely, data-driven lead selection * Design, optimize, and execute high-throughput assays (e.g., transfection, free uptake, qPCR/TaqMan, reporter assays) across diverse cell types * Partner with automation and engineering teams to expand and optimize automated workflows, improving throughput, robustness, and operational efficiency * Set and maintain high standards for data quality and reproducibility using assay metrics, controls, and QC frameworks * Identify and implement workflow improvements to accelerate timelines, increase throughput, and enhance data quality * Manage multiple programs in parallel, aligning priorities, timelines, and deliverables in a dynamic, matrixed environment Qualifications * Ph.D. with 2+ years, or M.S. with 10+ years of industry experience in molecular biology, pharmacology, or a related field * Experience in high-throughput screening and assay development in a drug discovery setting * Experience with RNAi, ASO, or other oligonucleotide-based therapeutics * Design, optimize, and execute high-throughput in vitro assays (e.g., transfection, free uptake, qPCR/TaqMan, reporter assays) across diverse cell types * Strong understanding of transfection and free-uptake systems across suspension and adherent cell models, including primary systems * Hands-on experience with laboratory automation platforms and scaling high-throughput operations * Familiarity with automated data capture and analysis platforms * Proven track record of delivering high-quality, reproducible data under tight timelines to inform decisions * Demonstrated experience mentoring scientists and leading complex workflows * Strong communication skills; able to provide clear, timely updates on program progress and key lab activities * Comfortable working at the bench alongside associates to execute and troubleshoot experiments Demonstrated success leading cross-functional initiatives and driving operational improvements #LI-JR1 U.S. Pay Range $110,400.00 - $165,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.