Finance and Operations Manager

At RefinedScience, our mission is to advance care by bringing together the best science, data and minds – disease by disease, patient by patient, cell by cell to discover pathways to life beyond disease.

We are seeking a highly capable and versatile Finance and Operations Manager to join our dynamic team. This is a broad, hands-on role that sits at the center of our day-to-day operations and partners across finance, reporting, legal, and contracting. As a ~40-person company, we still wear many hats, and this role is built for someone who thrives on variety, takes ownership, and wants to grow alongside the organization. You will start by supporting and executing core operational and financial workflows, and over time will have the opportunity to take ownership of functional areas as the company scales and further defines them.

The ideal candidate is detail-oriented, organized, and comfortable moving between accounting, contracts, expense review, and compliance in the same week. You are equally happy executing a process today and designing a better one for tomorrow.

This position reports to the Sr. Director of Strategic Operations and will work directly with them and a team of five consultants who currently make up the operations team.

This is a remote position. While the RefinedScience office is located in Aurora, CO, this role may be based remotely.

• Assist in the end-of-month close process, including working with our accounting team, doing reconciliations, and providing supporting schedules
• Review journal entries for accuracy in NetSuite. This role does not directly make journal entries.
• Lead project cost accounting and revenue recognition activities to ensure accurate and timely financials
• Assist with forecasting and budgeting processes, partnering with leadership on inputs and variance tracking
• Assist with cash flow and board reporting, preparing materials and supporting schedules for leadership and the board
• Support work with our annual financial audits
• Support monthly finance meetings for Laboratory, AI + Infrastructure, and C-suite review
• Review billing and expenses for accuracy, completeness, and proper documentation
• Approve expenses and manage workflows in Bill.com and ensure tracking and timely processing of invoices in coordination with the AP team.
• Track and support royalty and milestone obligations, ensuring commitments are met and recorded correctly
• Calculate and track tax obligations, including state and municipal tax, and provide supporting information to our tax team
• Contribute to internal reporting that helps leadership make informed decisions

• Assist with vendor contracting, including intake, review coordination, and tracking of agreements.
• Create and track purchase orders, ensuring proper approvals and accurate records
• Support the partner data licensing process from initiation through execution
• Maintain document retention practices and organized records across operational and legal functions

• Partner across finance, legal, and contracting to keep day-to-day operations running smoothly
• Help establish and refine scalable processes that support efficiency, compliance, and growth
• Step in where needed across the business, with the opportunity to grow into and take ownership of functional areas as the organization matures

• Bachelor’s degree in Accounting, Finance, Business, or a related field
• 6+ years of experience across accounting, finance, or operations roles
• Working familiarity with month-end close, revenue recognition, and cost accounting concepts
• Experience with Bill.com, NetSuite, or similar accounting and expense management platforms
• Strong proficiency with Microsoft Office tools (especially Excel) and comfort learning new systems
• Excellent attention to detail, organization, and follow-through
• Comfort working in a fast-moving, small-company environment where roles are still being defined

• Experience in an early-stage biotech, life sciences, or startup environment
• Exposure to vendor contracting, royalty/milestone obligations, multi-state tax, or data licensing agreements
• Track record of taking ownership of processes and growing into expanded responsibility

• Invest in Relationships – Building strong connections is the foundation for effective collaboration and trust for long-term success
• Embrace Agility – We celebrate agile thinking, resilience, and adaptability

At RefinedScience, we seamlessly integrate top-tier clinical and biological data with expert knowledge to provide unparalleled insights. We maximize patient impact with these unique insights by optimizing clinical trial probability of success and time to actionable results. We work across biopharma and we are a trusted partner in achieving better results, faster – working together to unlock strategic advantage.