CMC Supply Chain Manager

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

POSITION SUMMARY

The Supply Chain Manager is responsible for establishing, maintaining, and optimizing a robust supply chain to support preclinical and clinical development programs. This role ensures the timely and cost-effective supply of raw materials, Drug Substances (DS), and Drug Products (DP), while maintaining high standards of quality, compliance, and operational efficiency.

KEY RESPONSIBILITIES

• Develop and maintain a stable and reliable supply chain to support CMC production plans.
• Manage procurement and supply of raw materials, DS, and DP to ensure uninterrupted operations.
• Collaborate with internal stakeholders (CMC, QA, R&D, Clinical teams) to align supply plans with project timelines.
• Identify, evaluate, and onboard new suppliers to expand the supplier base and enhance supply flexibility.
• Conduct comprehensive supplier assessments, including capability, quality systems, reliability, and sustainability.
• Establish and maintain a supplier database with performance tracking and evaluation metrics.
• Continuously seek opportunities to reduce procurement costs and improve supplier performance.
• Manage vendor relationships, including regular communication and performance reviews.
• Manage the contracting process, ensure compliance with company procurement policies and procedures.
• Organize vendor meetings, prepare documentation, and coordinate logistics for cross-functional discussions.
• Track project progress and ensure alignment with supply chain timelines and milestones.
• Manage scope changes during project execution and initiate change orders as required.
• Support cross-functional project coordination to ensure smooth execution.
• Oversee logistics operations for DS, DP, and R&D samples, including shipping, storage, and distribution. Ensure compliance with regulatory and temperature-controlled logistics requirements.
• Maintain accurate inventory records and ensure optimal inventory levels to avoid shortages or overstocking.
• Manage vendor invoices and ensure billed activities are accurate and completed.
• Maintain proper documentation for procurement, logistics, and supplier management activities.

QUALIFICATIONS

• Bachelor’s (BSc) or Master’s (MSc) degree in Chemistry, Engineering, Pharmaceutical Sciences, or a related discipline is preferred.
• 5+ years’ experience in the biotech, pharmaceutical, or CDMO industry, with at least 3 +years specifically in CMC development, supply chain, PM or manufacturing.
• Proven experience in supplier sourcing, qualification, vendor management, supporting supply chains and working with DS/DP R&D and manufacture team.
• Understanding of pharmaceutical supply chain processes, including GMP/GLP/GCP requirements.
• Familiar with Sourcing processes including supplier development process, on boarding process, product cost-down process, and supplier phase-out process.
• Familiar with the RFQ process, and excellent cost and price analysis skills.
• Ability of working with external CDMO’s and experts in the delivery of projects.
• Strong CMC project management and cross-functional collaboration and stakeholder management skills.
• Excellent negotiation and communication skills.
• Ability to manage multiple priorities in a fast-paced environment.
• Detail-oriented with strong problem-solving abilities.
• A self-starter with the ability to work in a fast-paced environment and adapt quickly to changing needs and priorities; proven ability to prioritize and manage multiple tasks simultaneously.
• Occasional travel will be required
• Language required: English and Chinese