R&D Scientist

Agilent inspires and supports discoveries that advance the quality of life. We provide life science, diagnostic and applied market laboratories worldwide with instruments, services, consumables, applications and expertise. Agilent enables customers to gain the answers and insights they seek -- so they can do what they do best: improve the world around us. Information about Agilent is available at www.agilent.com.

The candidate will be responsible for leading and executing process research and development (R&D) activities for developing and optimizing enzymatic ligation and downstream processes at the lab scale for tech transfer to large-scale oligonucleotide production. Emphasis is on hands-on practical experience and expertise with a deep understanding of chemical/biochemical process and assay development and a strong background in purification and analytical techniques.

Essential duties and responsibilities include but are not limited to:

• Responsible for scientific and technical leadership of oligonucleotide process research and development focusing on enzymatic ligation technology

• Design and conduct laboratory scale experiments in a safe and effective manner with expertise in operating lab-scale chemical/biochemical process and analytical instruments.

• Accountable for planning, directing, and execution of technical work in developing and optimizing enzymatic ligation and downstream processes including ultrafiltration, diafiltration, and chromatography

• Responsible for analysis and reporting of specific data and presenting technical summaries in business settings

• Act as a liaison between laboratory and plant, facilitating the efficient development, tech-transfer, and implementation of oligonucleotide processes

• Maintain process compliance integrity by adhering to standard operating procedures (SOP’s) and current good manufacturing practices (cGMP) as appropriate

• Master’s Degree in chemistry, biochemistry, chemical engineering, biochemical engineering or related science discipline with five years of experience post-Masters in pharmaceutical process R&D

• Knowledge of enzymatic manipulation of DNA/RNA and biocatalysts

• Ph.D. with two years of industrial experience preferred

• Strong analytical and problem-solving skills, with the ability to lead and manage R&D projects

• Knowledge and experience in oligonucleotide process R&D, specifically with enzymatic ligation and downstream purification

• Strong communication skills and experience presenting technical summaries in business settings

• Strong desire and positive attitude to work in multi-disciplinary teams