Research Associate III - Spatial Biology

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The goal of the Brain Health accelerator is to revolutionize the treatment of brain diseases by creating the first dual-use molecular tools that can not only reveal information about the diversity of cells in the human brain but also be used to target novel treatments to specific types of cells.

We are seeking a Research Associate III to join the spatial biology team, which aims to spatially map cell type organization and composition and their alterations across a range of neurodegenerative brain disorders, such as Alzheimer’s Disease, Parkinson’s Disease, Lewy Body Dementia, Huntington’s Disease and ALS. Reporting to the senior manager, spatial biology, the ideal candidate will have deep experience in planning and executing high-throughput spatial transcriptomics assays on human tissue sections as well as performing quality control and data analysis. Strong organizational skills, attention to detail, and clear communication are essential.

At the Allen Institute, we believe that science is for everyone – and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly.

We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.

We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

• Run high-throughput spatial genomics workflows using custom experimental platforms including the MERFISH+ large format fluorescence microscopy-based technique
• Perform quality control and execute primary image analysis on the spatial genomics datasets
• Track and organize experimental data and metadata within and across experiments
• Maintain instruments to ensure proper performance and throughput
• Troubleshoot and optimize experimental protocols and workflows including contributing to and auditing standard operations procedures (SOPs)
• Contribute to a cohesive, multidisciplinary team to ensure scientific rigor and to support the scientific goals of the department and the scientific unit
• Maintain detailed and precise experimental records, generate presentations to communicate results, and share results rapidly and transparently with the team

Note: Reasonable accommodation may be provided to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

• Bachelor’s degree in neurobiology, cell biology, biochemistry or related field
• Minimum of 4 years of relevant experience
• Hands on experience working with advanced high-throughput microscopes
• Exceptional manual dexterity and attention to detail
• Basic understanding of neuroanatomy
• Proficient in Microsoft Office programs

• Experience with the MERFISH+ /MERSCOPE/Xenium spatial transcriptomics platform
• Experience with data science and developing computational infrastructure to optimize data acquisition, storage utilization, and computational resources
• Proficiency with Python or SQL-based automation tools
• Experience with automated data management and reporting workflows in support of spatial genomics experiments
• Familiarity with human neuroanatomy
• Exceptional manual dexterity and attention to detail
• Experience with sectioning, staining, and imaging brain tissues with fluorescent microscopy
• Excellent organizational and communication skills
• Ability to execute work and troubleshoot independently

• Frequently required to sit, stand, walk, stoop, kneel or reach
• Possible exposure to BioSafety Level 2 organisms, such as recombinant viruses
• Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances
• This may include wearing personnel protective equipment (PPE)

• Occasional lifting to 30 pounds
• Fine motor movements in fingers/hands to operate computers and other office equipment; lab equipment

• This is an onsite, M-F, regular business hours. This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with flexibility to work remotely on a limited basis.

• All employees who work with live animals must complete an Occupational Health medical history form and/or consultation with an Occupational Health Provider and receive clearance to work with animals. Depending on your health history and job responsibilities, an annual respiratory health screening and clearance to use a respirator may also be required.

• **Please note, this opportunity does not sponsor work visas **
• **Please note, this opportunity offers relocation assistance*
• Please include a cover letter with your application

$77,150 - $94,550 *

* Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable.