Senior Scientist - Functional Genomics, High-Throughput Screening

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will partner closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target discovery and prosecution; focused on the  adaptation and implementation of complex in vitro models to power target discovery and functional genomics efforts.

In this essential role for discovery at Amgen, you will be part of a dynamic, cross-functional team to advance target and biological discovery across Amgen’s therapeutic areas.

Key Responsibilities:
 

• →Collaborate with Amgen therapeutic area scientists to leverage appropriate cellular models, gene delivery methods, and perturbation techniques to capture disease-relevant biology. 

• →Design, optimize, and execute functional arrayed genomic screens in advanced in vitro models (e.g. iPSC-derived cell types, co-cultures, primary cells, organoids, etc.) 

• →Partner with TD&B and cross-functional team members, including automation colleagues, to accelerate model deployment and reproducibility. 

• →Identify and implement emerging technologies in high content imaging, cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms. 

• →Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline. 

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications.

Doctorate degree PhD

OR

PharmD

OR

MD [and relevant post-doc where applicable]

OR

Master’s degree and 3 years of functional genomic screening experience

OR

Bachelor’s degree and 5 years of functional genomic screening experience

• Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline 

• Functional genomic screening experience; arrayed CRISPR (KO/i/a) and perturbation screening experience preferred; experience in high-throughput or automated screening preferred 

• Strong track record in cell engineering and complex in vitro model development 

• Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation 

• Experience with high-content imaging, automated microscopy, image analysis, feature reduction, and multivariate analysis preferred 

• Familiarity with high-throughput screening metrics (e.g. Z’, S/B, MSMR) 

• Cell culture experience; iPSC experience and work in complex in vitro cellular models preferred 

• Experience with bioinformatics and computational analyses to harness meaningful results from genome-wide datasets 

• Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models 

• Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights 

• Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment 

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.