Founder in Residence, Unlocking systemic drug delivery for brain & CNS disease

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Requirements Summary

Protein Engineering Experience leading protein engineering strategy, protein design, structural analysis, and sequence motif analysis; Lead generation campaigns, screening cascades,

Technical Tools

OtherEntrepreneur In Residence

Requirements

~1 min read

We are interested in a variety of technical backgrounds. The most important requirement is deep expertise in at least two of the following four areas:

Protein Engineering

Experience leading protein engineering strategy, protein design, structural analysis, and sequence motif analysis;
Lead generation campaigns, screening cascades, computational modelling & AI/ML tools;
Antibody lead generation (in silico or immunisation) & optimisation;
Synthetic biology: mini proteins, cell-penetrating peptides, endosomal escape peptides, membrane insertion peptides.

Biologics Drug Development

Experience across diverse modalities: bispecific antibodies, protein fusions, antibody conjugates, Fc engineering, synthetic proteins, macrocyclic peptides;
Discovery & pre-clinical development (target ID, target validation, lead generation, lead optimisation, DC, IND);
Developability (PK/PD, ADME, Toxicology, CMC);
In vitro and in vivo pharmacology and study design for protein biologics.

Cell Biology & Neurobiology

Intracellular trafficking, endocytosis, adaptor proteins, endosomal sorting, tubule formation, kinesin transport;
Blood-brain barrier biology, endothelial cell biology, transcytosis, receptor-mediated transcytosis (RMT), carrier-mediated transcytosis (CMT);
CNS disease biology (AD, PD, MS, and other neurological conditions);
Human BBB translational models (e.g. in vitro iPSC-derived BBB models).

Medicinal Chemistry

Small molecule conjugates, cleavable linkers, molecular glues, degraders;
Experience in CNS-penetrant small molecule design and efflux transporter biology.

Track record of translating scientific concepts from discovery through to in vivo proof-of-concept or IND;
Experience managing CRO/CDMO or Pharma programmes and building regulator- or investor-ready data packages;
You are highly motivated by unsolved challenges in CNS drug delivery, and driven to challenge the status quo of how we treat brain diseases;
You are impact driven, take the initiative, make things happen, and can think from a first principles perspective to figure out what’s really needed;
You have clear entrepreneurial spirit and mindset, demonstrated through impactful innovation, and an ability to work in ambiguous, unstructured but fast-paced, demanding and pressurised environments;
Collaborative nature, with the ability to work effectively in cross-functional teams.

Nice to Have

~1 min read

CNS preclinical or clinical drug development experience;
Single-cell transcriptomic data analysis;
Target & biomarker identification;
Deep understanding of IP - FTO and patentability, with a track record of patents in this field;
Track record of publications and/or thought leadership in CNS delivery or related fields;
Previous biotech founder or C-suite leadership experience;
Previous fundraising experience (VC, dilutive or non-dilutive);
Experience building and leading successful scientific or cross-functional teams;
Network across CNS pharma, biotech, or relevant academic institutions.

What We Offer

~2 min read

By joining DSV, you’ll be joining a team of operators who have founded companies and led translation of science at some of the most respected universities, charities, funds and government agencies. 2/3 of the team have founded or led a company at C-suite and 65% have a PhD. Our team dedicate several hours every week to each Founder or founding team to provide tailored guidance, resources and feedback covering every aspect of what it takes to successfully launch a new venture from both the tech and commercial perspectives:

✓We provide optimised, purpose-built, proprietary tools, resources and processes to help create high-impact ventures from scratch, using our venture creation methodology;

✓DSV and the Partners’ extensive network, technical, commercial and fundraising domain expertise, and wide-ranging portfolio company capabilities;

✓We jointly provide an initial £250k (~$330k / €290k) investment governed by our Investment Committee to incorporate the new venture and develop early proof-of-concept data that is often needed to attract high profile non-venture studio VCs. This funding is also key for obtaining grant funding, which often needs to be matched with private investment;

✓You and your co-founder(s) together will own the majority equity stake in the company;

✓We provide minimum guaranteed income of £4,166 per month (fixed), paid to each Founder as a consultancy fee until the company is launched and pre-seed investment is secured;

✓We provide continuous support post spin-out, including fundraising, commercial partnerships, recruitment and team-building (amongst other things);

✓Other Founders currently at DSV across sectors working collaboratively and supporting one another - a unique resource to draw on.

Deep Science Ventures (DSV) is on a mission to create a future in which both humans and the planet can thrive. We use our unique venture creation process to create, spin-out, and invest in science companies, combining available scientific knowledge and founder-type scientists into high-impact ventures. Operating in four sectors - Pharmaceuticals, Climate, Agriculture, and Computation - we tackle the challenges defining these areas by taking a first principles approach and partnering with leading institutions.