Senior Scientist, Process Development (Watertown, MA)

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Overview

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Key Responsibilities

Culture and purify different cell types including iPSC and MSC cells. Maintain small-scale bioreactors from 0.5mL to 10L scale. Cell transfection, transduction, and other genetic manipulation techniques.

Requirements Summary

Bachelor’s degree with minimum 10 years relevant experience or Ph.D with 2-4 years’ experience in biology, bioengineering, biotechnology, or related discipline. Strong understanding of tissue culture and aseptic technique.

Technical Tools

data-analysis

We are seeking a highly motivated and team-oriented professional with entrepreneurial spirit to join our company! This is an exciting opportunity for a well-qualified candidate to join a rapidly growing company focused on turning today’s cutting-edge research into tomorrow’s breakthrough therapies. We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects. The ideal candidate will be involved in troubleshooting complex issues. The position requires a strong understanding of all aspects of mammalian cell culture and aseptic technique, ability to use small-scale bioreactors and purification principles, and experience in data analysis and scientific writing. This is a hands-on lab-based position requiring a flexible schedule based on experimental work; some weekend work may be required.

Responsibilities:

Culture and purify different cell types including iPSC and MSC cells.
Maintain small-scale bioreactors from 0.5mL to 10L scale.
Cell transfection, transduction, and other genetic manipulation techniques.
Use of purification techniques such as affinity and anion exchange chromatography and filtration-based unit operations.
Performance of general laboratory tasks, including maintenance of equipment.
Maintain accurate and reliable records including database management, batch records, lab notebooks, and all other pertinent documentation.
Write and/or contribute to SOPs, batch records, protocols and reports.
Comply with all safety and infection control standards.

Qualifications:

Bachelor’s degree with minimum 10 years relevant experience or Ph.D with 2-4 years’ experience in biology, bioengineering, biotechnology, or related discipline.
Strong understanding of tissue culture and aseptic technique.
Willingness to work with different viral vector systems (lentiviral and AAV) and biological samples.
Strong team worker who is also independently motivated, detail oriented with good problem-solving capabilities.
Strong verbal and written skills; able to handle confidential information and material appropriately.
Background in cell-based methods and bioreactors and/or downstream purification experience.

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