Engineer, Process Sciences - Upstream

Encoded Therapeutics is a clinical-stage genetic medicines company developing potentially disease-modifying therapies to improve the lives of people with severe CNS disorders. Our proprietary vector engineering approach combines novel regulatory elements and payloads with AAV vectors to unlock innovative solutions for debilitating, intractable CNS conditions. At the forefront is our flagship clinical program, ETX101 for Dravet syndrome, which targets the underlying cause of the disorder to enable highly selective upregulation of SCN1A for potentially long-lasting benefit. In parallel, we are advancing a pipeline of potentially best-in-class programs to address significant unmet needs across both monogenic and prevalent CNS conditions. For more information, please visit www.encoded.com.

We are recruiting an Engineer, Process Sciences to join our team. This is a unique opportunity to work at the intersection of genomics and therapeutics and participate in the development of a diverse therapeutic pipeline driven by a transformative core technology. The successful candidate will work well across multiple projects in a fast-paced and dynamic environment.

• →Design, execute, and analyze small-scale studies supporting the development of two at-scale products and Encoded’s pipeline products
• →Serve as an engineer responsible for pre-clinical and clinical manufacturing for AAV projects and plasmid manufacturing; including upstream, downstream, fill finish, and drug device
• →Facilitate Encoded’s technology transfer of manufacturing processes to non-GMP/GMP internal and external sites of manufacturing
• →Provide person-in-plant support of GMP (clinical and commercial) manufacturing as required at internal and external sites of manufacturing
• →Work with cross-functional teams to develop tools/templates to support tech transfer business processes

• B.S or M.S. in a relevant area of specialization (biochemical engineering, chemical engineering, biological sciences, virology, molecular biology, or biochemistry)
• At least 3 years of industry experience or equivalent educational experience
• At least 1 year of industry experience in MSAT/PD/Process Sciences role preferred
• Extensive working knowledge of modern laboratory procedures and knowledge of cGMP is a must
• Ability to independently design, execute, and analyze small-scale cell culture studies (cell expansion, single-use bioreactors, and harvest/clarification) is a must
• Must be a team player and exhibit a willingness to meet project timelines
• Strong verbal and written skills are required as well as effective interpersonal, technical, and troubleshooting skills
• Outstanding planning, organization, and multitasking skills
• Experience with gene therapy processes is strongly preferred