Director, Toxicology

• Lead toxicology and safety pharmacology activities across multiple discovery and development programs, including oversight of internal teams, consultants, and external partners.
• Develop and execute integrated nonclinical safety strategies aligned with program, regulatory, and organizational priorities.
• Direct the design, execution, interpretation, and reporting of GLP and non-GLP toxicology studies, including in vitro, general, reproductive, developmental, genetic, and specialized toxicology assessments, and safety pharmacology.
• Drive cross-functional alignment on study plans, scientific findings, risks, decisions, and program priorities.
• Manage resources, budgets, CROs, and functional processes to ensure quality, compliance, efficiency, and timely delivery.  
• Set clear goals, drive accountability, and develop scientific talent to build a collaborative, high-performing team.

• Ph.D., DVM, or equivalent advanced degree in toxicology, pharmacology, or a related scientific discipline, with significant experience leading nonclinical safety activities in a biotechnology, pharmaceutical, or comparable industry setting.
• Experience as the toxicology lead on successful IND, CTA or  NDA submissions, including direct regulatory agency interactions.
• 10+ years of relevant toxicology or safety assessment experience with demonstrated progression into scientific and people leadership roles, including hands-on experience designing study protocols and managing CROs.
• Advanced scientific expertise in general toxicology, safety pharmacology, developmental and reproductive toxicity, carcinogenicity, in vitro toxicology, study design, data integration and interpretation, risk assessment, and global regulatory requirements, including FDA, EMA, and ICH.
• Proven ability to lead complex research or development programs across internal and external teams, translate scientific strategy into executable plans, and deliver critical milestones through influence, collaboration, and sound scientific judgment.
• Experience managing scientific teams, external partners, operational plans, resources, and budgets, with a track record of establishing clear expectations, coaching talent, addressing performance, and building organizational capability.
• Strong communication and cross-functional influencing skills, including the ability to clarify needs, influence decisions using data and logic, navigate ambiguity, resolve conflicts constructively, and communicate complex scientific data to senior leadership and regulatory authorities.

• Board certification in toxicology, such as DABT, or an equivalent professional credential.
• Experience leading toxicology strategy across programs ranging from development candidate selection through late-stage clinical development or registration.
• Expertise in emerging toxicology methodologies, translational safety approaches, alternative nonclinical models, or novel drug modalities.
• Demonstrated success building or scaling a toxicology function, introducing improved processes, and influencing scientific investments across a research organization.

Please complete the application below and include the following attachments:

• Cover Letter
• CV / Resume
• Research Summary (if applicable)

Enanta is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs with an emphasis on indications in virology and immunology. Enanta’s clinical programs are currently focused on respiratory syncytial virus (RSV) and its earlier-stage immunology pipeline aims to develop treatments for inflammatory diseases by targeting key drivers of the type 2 immune response, including KIT, STAT6 and MRGPRX2 inhibition.

Glecaprevir, a protease inhibitor discovered by Enanta, is part of one of the leading treatment regimens for curing hepatitis C virus (HCV) infection and is sold by AbbVie in numerous countries under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). A portion of Enanta’s royalties from HCV products developed under its collaboration with AbbVie contribute ongoing funding to Enanta’s operations. Please visit www.enanta.com for more information.

Enanta Pharmaceuticals is an equal opportunity employer (EOE) with a commitment to diversity. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to race, color, national origin, age, religious creed, gender, gender identity, sexual orientation, physical or mental disability, protected veteran status, or any other class protected by law.