Senior Manager, Total Rewards

At Freenome, we are seeking a Senior Manager, Total Rewards for a role with high ownership, strategic influence, and direct execution. You will lead and co-own our end-to-end total rewards strategy, equally balancing strategic design and hands-on operational leadership across both compensation and benefits programs as a newly public company. This role is responsible for overseeing and personally executing recurring processes, resolving complex employee and vendor escalations, and maintaining rigor, administrative accuracy, and compliance across all program workflows.

This role is expected to partner closely with People, Payroll, Finance, Legal, brokers, carriers, and other external advisors. They bring sound judgment, strong follow-through execution, and an understanding of the confidentiality, documentation, controls, and cross-functional coordination required in a public-company environment. This is a senior individual contributor role with meaningful program ownership and influence. You will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer.

The role reports to the Senior Director, Total Rewards and Talent Acquisition. This will be a Hybrid role (3-4 days/week) based in our Brisbane, California headquarters.

• Build, maintain, and directly manage standard operating procedures (SOPs), administrative calendars, tracking sheets, and internal SOX control checklists.
• Own Total Rewards projects end-to-end, taking full responsibility for defining task steps, driving timelines, executing deliverables, and resolving roadblocks independently.
• Build effective working relationships across People, Finance, Payroll, Legal, and external partners.
• Identify opportunities to improve data quality, vendor service, administrative efficiency, and employee experience; recommend and help implement practical solutions.
• Use sound judgment and discretion when handling sensitive employee matters and confidential benefits, compensation, and equity-related information.

• Bachelor’s degree or equivalent practical experience in Human Resources, Business, or a related field.
• Minimum 8+ years of progressive experience in benefits, compensation, total rewards, or HR operations, including direct experience in the biotechnology or life sciences industry.
• Experience supporting Total Rewards programs at a publicly traded company, with an understanding of the related confidentiality, documentation, controls, and cross-functional coordination needs.
• Hands-on experience administering health and welfare benefits and partnering with brokers, carriers, vendors, Payroll, and HR systems.
• Experience supporting compensation processes such as market benchmarking, salary range administration, annual compensation planning, bonus or incentive programs, or equity administration.
• Strong analytical and organizational skills, including the ability to reconcile data, investigate discrepancies, and manage recurring deadlines.
• Proficiency with HRIS and benefits systems and strong spreadsheet skills.
• Clear written and verbal communication skills, especially when explaining programs and resolving employee questions.
• Ability to manage work independently, prioritize competing needs, and know when to involve the appropriate partner or leader.
• Fluency and practical proficiency with modern AI tools and technology (e.g., ChatGPT, Gemini, HR automation tools) alongside standard office software to drive efficiency, data analysis, and process optimization.
• Sound judgment and discretion when handling confidential information.

• Experience in a growing life sciences company or an environment with evolving programs and processes.
• Familiarity with benefits compliance coordination and working with external advisors.
• Experience supporting public-company compensation, equity, audit, or reporting processes.
• Experience documenting procedures, improving workflows, or leading cross-functional projects.