Empress: Proteomics Co-Op

Empress is pioneering mechanistic intelligence for drug discovery — helping R&D teams understand what their molecules are doing, what is driving activity, what liabilities may emerge, and which candidates are best positioned to advance. By integrating multi-omics, chemoproteomics, proteomics, transcriptomics, computational inference, knowledge graphs, and CRISPR-based functional validation, Empress turns biological complexity into clearer development decisions. Our platform gives discovery teams access to capabilities that would otherwise require years, specialized infrastructure, and rare cross-functional expertise to build internally.

We're looking for a Co-Op to join our Proteomics team and contribute to the development of Empress's Integromyx and Perturb-seq platforms. You'll get hands-on experience across the full mass spectrometry-based proteomics workflows, from cell culture and sample preparation through LC-MS/MS acquisition on Orbitrap systems, including exposure to chemoproteomics experiments that sit at the intersection of chemistry and biology.

You'll work as part of a cross-functional team where your contributions matter from day one. We're looking for someone who is curious, detail-oriented, and eager to develop their skills alongside a team building something new.

• →Set up, maintain, and operate Orbitrap mass spectrometry and associated liquid chromatography systems
• →Maintain mammalian cell cultures; prepare growth media and expand cells for experiment setup
• →Execute proteomics sample preparation workflows including protein extraction, fractionation, and LC-MS analysis
• →Use laboratory automation for sample preparation and processing
• →Contribute to proteomics and chemoproteomics experiments and support data analysis
• →Present findings in team and cross-functional meetings; maintain meticulous electronic lab notebook records

• Currently enrolled in a B.S. or M.S. program in Chemistry, Chemical Biology, Biochemistry, or a related field
• Coursework or hands-on laboratory experience in chemical biology, liquid chromatography, or mass spectrometry

• Familiarity with analytical techniques with a focus on mass spectrometry, especially Thermo Fisher instrumentation
• Experience with liquid chromatography sample preparation and purification
• Familiarity with R, Python, or strong interest in learning informatics tools
• Interest in lab automation instrumentation
• Prior experience with mammalian cell culture