ProFound Therapeutics: Proteomics Co-Op

ProFound Therapeutics Inc. is a privately held, early-stage biotechnology company with the vision to revolutionize the human therapeutic landscape. ProFound has recently made the news by being included in the Fierce Biotech’s list of the hottest Biotech companies. ProFound Therapeutics Inc. was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 75 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics (NASDAQ:MRNA), Seres Therapeutics (MCRB), Syros Pharmaceuticals (SYRS), Evelo Biosciences (EVLO), Kaleido Biosciences (KLDO), and Indigo Agriculture. ProFound Therapeutics, Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our team.

Welcome to Flagship Pioneering Co-Op Program for the cohort dreaming big and taking courageous leaps. You'll join fellow peers across our ecosystem of companies and learning firsthand how we build first-in-category companies. You’ll have access to enrichment sessions, a dedicated professional development track, and a mentor that help guide you toward your next step. By the end, you will carry on a meaningful project outcome, a genuine network, and a front-row view of how Flagship pioneer new ventures that change the world.

ProFound Therapeutics is seeking an innovative and highly motivated Co-Op with experience in protein biochemistry and/or mass spectrometry to play a vital role in the company’s Proteomics team. Under the supervision of senior scientists on the Proteomics team, this individual will receive structured training and hands-on experience in proteomics sample preparation, LC-MS/MS analysis, and the development of workflows for challenging protein classes. This individual will contribute scientific and technical expertise to a multidisciplinary team, emphasizing conceptualization, experimentation, data analysis, presentation, and strategic planning. The ideal candidate for this position will have coursework or early research experience in biochemistry, analytical chemistry, cell biology, or a related discipline and be enthusiastic and capable of working in a multidisciplinary (e.g. genomics, bioinformatics, protein biochemistry) team in the biosciences. The candidate should be able to work independently and as part of a team in a fast-paced entrepreneurial setting. The Co-Op is designed to complement the candidate’s academic training and provide exposure to industry-based research and therapeutic development.

Key Responsibilities 

• Serve as a contributor to the Proteomics team, whose mission is to discover new therapeutics and validate new therapeutic targets
• Support the development of workflows using alternative proteases to improve protein sequence coverage and detection of challenging proteins
• Assist with the optimization of surfaceome enrichment and profiling of cell-surface and membrane proteins
• Assist with the optimization of secretome proteomics workflows for conditioned media, including strategies to minimize serum interference and intracellular contamination
• Assist with the optimization of ubiquitylation screening, including enrichment and analysis of ubiquitin-remnant peptides
• Perform proteomics sample preparation, LC-MS/MS analysis, data interpretation, and quality control, supported by senior scientists
• Troubleshoot methods, document results, and contribute to establishing reproducible protocols
• Organize and maintain experimental records in Benchling for review
• Report experimental plans and results to the scientific team
• Proactively review literature to contribute to new ideas and methods/technologies for discovery and therapeutic areas

• Pursuing a Bachelor’s or Master’s degree in biochemistry, chemistry, analytical chemistry, cell biology, or a related field
• Coursework or hands-on laboratory experience in protein biochemistry, cell biology, proteomics, or mass spectrometry, and attention to detail
• Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
• Strong collaborative skills with evidence of working in a team

• Prior industry or academic research co-op experience in proteomics, protein biochemistry, or mass spectrometry
• Experience with LC-MS/MS sample preparation
• Coursework or research exposure to membrane proteins, secretome analysis, or post-translational modification (PTM) enrichment
• Familiarity with proteomics data analysis software
• Confident execution, focused and team-oriented with an ability to thrive in an entrepreneurial environment
• Experience with data analysis using Graphpad Prism and Microsoft Excel