Associate Principal / Principal Scientist (Protein Science)

Singaporelead

OtherAssociate

0 views0 saves0 applied

Apply Now

Quick Summary

Key Responsibilities

Biologics Production Leadership: Develop, triage, implement, and troubleshoot innovative strategies for the design and engineering of complex antibody formats (bispecifics, multivalent, Fc-fusions,

Requirements Summary

Ph.D., in Biochemistry, Molecular Biology, Cell Biology, Structural Biology, Bioengineering or a related field. At least 5 years of experience in antibody design, protein expression, and purification,

Technical Tools

OtherAssociate

Responsibilities

~1 min read

Develop, triage, implement, and troubleshoot innovative strategies for the design and engineering of complex antibody formats (bispecifics, multivalent, Fc-fusions, VHH). to achieve high yields, purity, and functionality.
Design and manage a portfolio of projects to provide data-driven, structure-function insights to improve expression, stability, and manufacturability.
Oversee a team of research associates and/or biotechnologists, providing technical guidance and fostering a culture of excellence in protein science methodologies.

Collaborate with cross-functional and cross-cultural teams to support the development of biologics, with a focus on evaluate and translate new technologies into production-ready solutions.
Periodically review internal and external advancements in:
- Antibody formats and engineering strategies
- Upstream and downstream integration impacts driven by molecule design
Assess readiness of new technologies for tech transfer, including:
- Fit-for-purpose application across different molecule classes
- Scalability and reproducibility
- Impact on quality attributes (aggregation, mispairing, heterogeneity)
- Act as a scientific bridge between R&D innovation and operational deployment, ensuring:
  1. New platforms are not only scientifically sound but also translatable to production workflows
  2. Design decisions are aligned with manufacturing realities
- Partner with internal stakeholders (e.g., Quality Assurance, Process Development, and Manufacturing) to ensure alignment and efficiency in biologics production workflows.

Develop and integrate AI-assisted design-for-manufacturability frameworks, leveraging internal datasets and external computational tools (e.g., structure prediction, developability scoring) to proactively identify and mitigate risks such as aggregation, mispairing, and low expression in complex antibody formats.
Lead or support AI-enabled design and innovation initiatives (internal and external partnerships, including governmental or consortium projects) by translating computational design outputs into experimentally validated constructs, and ensuring alignment between in silico design predictions and real-world expression, quality, and manufacturability outcomes.

Requirements

~2 min read

Ph.D., in Biochemistry, Molecular Biology, Cell Biology, Structural Biology, Bioengineering or a related field.
At least 5 years of experience in antibody design, protein expression, and purification, preferably in an industrial setting.
Strong expertise in bispecific design and troubleshooting expression challenges.
A demonstrated record of success with protein engineering for enhanced protein expression or properties.
Experience with the biophysical characterization of proteins and the assessment of protein-protein interactions.
Familiarity with automation and high-throughput techniques for protein expression and purification.
Strong analytical and problem-solving skills, with a wide ranging experience in analytical techniques such as SPR, and mass spectrometry.
Excellent written and verbal English communication skills, with a track record of scientific publications, presentations, and conferences.

GenScript USA Inc/ProBio Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is the Company's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

GenScript USA Inc./ProBio Inc. maintains a drug-free workplace.

Please note: Genscript USA Inc./ProBio Inc. will only contact candidates through verified application sources. GenScript/Probio does not request personal information from candidates through individual email or any other platform.