Scientist, Upstream Process Development

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for a Scientist, Upstream Process Development to be in Spring House, PA.

The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processes for in vivo therapeutic programs. This role will contribute to early- through clinical-stage process development, with emphasis on bioreactor execution, media and process optimization, scale-down model generation, and data-driven process understanding for next-generation biologics and genetic medicines. 

• Design and execute upstream process development studies for lentiviral in vivo therapeutic products under scientific guidance. 

• Perform cell culture experiments using shake flasks, bench-scale bioreactors, and automated high-throughput systems. 

• Support development of scalable fed-batch and perfusion processes to improve productivity, quality, and manufacturability. 

• Utilize Ambr® 250 bioreactor systems for process development, media optimization, and scale-down model studies. 

• Apply statistical experimental design, data analytics, and visualization tools to support process understanding and decision-making. 

• Build working knowledge of Process Analytical Technology, Raman spectroscopy, online monitoring, and digital bioprocessing tools. 

• Analyze and interpret process data using JMP, MiniTab, Python, Spotfire, or similar platforms. 

• Support evaluation of novel upstream technologies that improve process robustness and development efficiency. 

• Collaborate with downstream, analytical, automation, modeling, and formulation teams to align study design and deliverables. 

• Author technical reports, development summaries, protocols, and regulatory-supporting documentation.