Manifoldbio~1mo ago

Director, Oligo Team Lead

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OtherManagementDirectorTeam Lead

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Quick Summary

Overview

Key Responsibilities

Build and lead a fit-for-purpose oligonucleotide therapeutic discovery team that includes both internal and outsourced expertise and capabilities, as needed.

Requirements Summary

PhD in a relevant field (chemistry, biochemistry, nucleic acid chemistry/biology, biophysics, molecular biology, pharmacology or related discipline) Minimum of 10 years post-PhD experience, including experience in industry drug-discovery programs…

Technical Tools

OtherManagementDirectorTeam Lead

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists work across this full stack to pursue programs both internally and with leading pharma companies.

Responsibilities

~1 min read

→Build and lead a fit-for-purpose oligonucleotide therapeutic discovery team that includes both internal and outsourced expertise and capabilities, as needed.
→Lead 1-2 cross-functional drug discovery project teams, collaborating closely with protein engineers, in vitro biologists, bioconjugation scientists, and in vivo biologists to discover and progress shuttled oligo-based therapeutics.
→Work with company leadership and cross-functional experts to prioritize high-value therapeutic targets for tissue-targeted oligo therapeutics.
→Define best-in-class target product profiles for tissue-targeted therapeutic oligonucleotides. Define workplans and track progress to deliver on those target product profiles.
→Closely track advances in the field and provide strategic direction for continued development and expansion of Manifold’s shuttled oligo discovery efforts.
→Clearly communicate scientific progress and challenges to team members, leadership, and internal/external collaborators
→Establish and optimize innovative, efficient screening and production systems that leverage Manifold’s multiplexed in vivo screening capabilities.
→Serve as oligonucleotide therapeutic subject matter expert in discussions with potential partners, collaborators, and investors

Requirements

~1 min read

PhD in a relevant field (chemistry, biochemistry, nucleic acid chemistry/biology, biophysics, molecular biology, pharmacology or related discipline)
Minimum of 10 years post-PhD experience, including experience in industry drug-discovery programs
Diverse experience with multiple oligonucleotide modalities (ASOs, siRNAs, aptamers, mRNA), different backbone chemistries/modifications
Knowledge of proven and emerging technologies for delivering oligo medicines to cellular targets (LNPs, passive or active targeting moieties, etc.)
Experience progressing oligonucleotide therapies from early discovery through IND-enabling preclinical activities / early clinical development
Demonstrated leadership of effective specialized and cross-functional scientific teams
Demonstrated ability to mentor junior scientists
Excellent written and verbal communication skills

Requirements

~1 min read

Experience designing and interpreting in vitro and in vivo systems assessing oligonucleotide efficacy and safety
Strong background in the engineering of optimized oligonucleotide conjugates, including linker discovery and bioconjugation optimization
Experience building and/or optimizing platforms for oligo design, synthesis, and screening
Understanding of DMPK, toxicology, developability, and CMC considerations specific to oligos
Track record of successful partnerships and external collaborations

Base Salary Range: $195,000-239,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

Annual performance-based target bonus
Stock options
Comprehensive medical, dental, and vision coverage
401(k) plan
Flexible paid time off and holidays
Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.