Postdoctoral Fellow-MSH-13500-003

Salary: - $73,588.09

Department: Surgery 

Physical work location: Annenberg, 25^th Fl, RM A25-98

Name PI or Supervisor: Alan Dardik, MD, PhD

Web link to Lab: N/A (in process)

Web link to Department: https://www.mountsinai.org/care/surgery

Administrative Contact: (phone and email) Stella Cherepashensky, 212-241-7120, stella.cherepashensky@mountsinai.org

This research project is an advanced vascular research project in the Dardik laboratory that focuses on arteriovenous fistula (AVF) maturation and examines the role of diabetes during AVF maturation. This project uses human specimens, the mouse aortocaval model, as well as in vitro and computational models.

This project requires scientific laboratory performance at an advanced level requiring advanced molecular skills and analysis such as qPCR, Western blotting, immunohistochemistry, and microsurgery in small animals including husbandry and analysis of different strains of mice (including diabetic mice and knockout mice), as well as imaging techniques including ultrasound and CT scans. Statistical and computational analyses are required. Advanced surgical experience is required to perform both small animal surgery and to participate in large animal surgeries; analysis of human samples (obtained from the operating room) is also required.

Successful completion of professional training, either MD or PhD degree required, with both preferred. Professional proficiency of English language skills is required, including both verbal and written proficiency. Evidence of professionalism in research including ethical treatment of human and animal subjects. Compliance with all local, institutional, state and federal regulations. The ability to successfully work with others in teams is required, including other laboratory members as well as with collaborators and institutional officials.

Experience with clinical surgery (in humans) required, vascular surgery preferred, with successful completion of postgraduate training. Experience with molecular biology techniques required, including use of qPCR, Western blotting, immunohistochemistry, immunofluorescence, and tissue culture. Experience with small animal surgery (in mice) required. Experience using doppler ultrasound required. Experience writing and maintaining animal protocols and approvals is required, as well as experience writing and publishing papers in the medical and scientific literature.

A successful outcome of this project is to determine the effects of diabetes during AVF maturation and on AVF patency. In addition, publication of the results in the scientific literature is important and presentation of the results at professional meetings is encouraged. Adherence to all professional standards (including conduct, ethics, professionalism, legal) during the course of the project is expected.