Postdoctoral Fellow-MSH

Roles & Responsibilities:

The Guccione Lab at the Icahn School of Medicine at Mount Sinai recently identified that inhibiting spliceosomal assembly through inhibition of arginine methylation provides an effective means of therapeutic splicing inhibition. Specifically, inhibiting either symmetric arginine methylation (mediated by the protein arginine methyltransferase 5 -PRMT5) or asymmetric dimethyl arginine methylation (mediated by type I PRMTs (PRMT1, 3, 4, and 6)) reduces splicing fidelity resulting in strong preferential killing of (i) splicing factor-mutant leukemias and (ii) MYC-overexpressing lymphomas over their wildtype counterparts. In addition the lab is investigating the role of members of the PRDM family of enzymes (e.g. PRDM9, PRDM10, PRDM15), in liver and colorectal cancer.

The successful applicant will be part of a highly productive research team studying transcription and post-transcriptional regulation in the context of cancer, with direct translational applicability. Applicants should be highly motivated and driven to study cancer epigenetics and RNA biology.

The successful candidate will be part of a thriving environment in the Department of Oncological Sciences within the Tisch Cancer Institute. The position offers competitive salary, subsidized postdoc-housing and exposure to a rich environment at Icahn School of Medicine at Mount Sinai and NYC.

Requirements:

• PhD in molecular biology or similar
• Strong background in working with murine tumor models is a plus.
• Background in cancer, RNA/chromatin biology and familiarity with recent advances in these fields and NGS technologies is a plus.
• Excellent communication skills. Must be able to work as part of a small team and report data clearly.
• Proactive and problem-solving attitude is important

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