Postdoctoral Fellow-MSH-30040-232

Web link to Department: https://icahn.mssm.edu/about/departments/pharmacological-sciences

Administrative Contact: (phone and email): Yoori Kim, 212-6598651, yoori.kim@mssm.edu

Details of Research Project: 

Dr. Jian Jin’s lab is a leader in discovering selective inhibitors of protein methyltransferases (PMTs), biased ligands of G protein-coupled receptors (GPCRs), and small-molecule degraders of oncoproteins and stabilizers of tumor suppressors, as well as in developing innovative technologies for advancing the targeted protein degradation (TPD), targeted protein stabilization (TPS), and targeted protein acetylation (TPA) fields. This chemical biology and drug discovery project will involve design, synthesis, and testing of new compounds to develop novel therapeutics for treating various human diseases including cancer as well as development of new technologies to advance the research fields described above.

Technical Duties: 

The main responsibilities include: (1) design and synthesize molecules of interest; (2) perform analyses to confirm the identity and purity of the synthesized products; (3) test the synthesized compounds in biochemical and cellular assays, (4) analyze data and prepare reports for review with Dr. Jian Jin and other lab members; (5) document all work according to standard procedures; (6) prepare or contribute to publications and grant applications; (7) prepare and present materials at seminars and meetings; (8) comply with all safety rules; and (9) maintain the lab equipment related to the research.

Educational and other Requirements for the position: PhD

Administrative Contact: (phone and email): Yoori Kim, 212-6598651, yoori.kim@mssm.edu

Educational and other Requirements for the position: PhD

Experience Required:

Experience in synthesis of small molecules by using parallel, multistep synthetic organic chemistry techniques is required. Experience in small molecule purification via chromatography techniques such as flash column chromatography and liquid chromatography as well as techniques in characterization of the small molecules via NMR and LCMS is required. Experience in testing compounds in biochemical and cellular assays is also required

Goals/Outcomes of the Research Project: 

Successful outcome of the project would be discovery of novel compounds as chemical biology tools and/or preclinical drug candidates to study and/or treat human diseases such as cancer and publication of research results to advance relevant research fields.