Postdoctoral Fellow-MSH-32076-175

Salary: According to UAW/Mount Sinai agreement, starting salary $74,692

Department: 866 – Department of Immunology and Immunotherapy

Location: Hess – 1470 Madison Ave., 5^th & 6^th Floors, New York, NY 10029

                             West Campus – 619 W. 54^th St., 9^th Floor, New York, NY 10019

Department website: https://icahn.mssm.edu/about/departments-offices/immunology-immunotherapy

Laboratory website: https://icahn.mssm.edu/research/human-immune-monitoring-center

The Department of Immunology and Immunotherapy, Division of Human Immune Monitoring Center (HIMC) is seeking highly motivated postdocs to lead projects aimed at supporting translational and clinical research within an Immune Monitoring Center by analyzing high-plex immunologic datasets generated across diverse diseases, tissues and patient cohorts. This role works closely with immunologists, clinicians, wet-laboratory scientists, and computational researchers to characterize immune-cell populations, cellular states, regulatory programs, and tissue-specific immune responses. This position is responsible for the end-to-end processing and analysis of bulk, single-cell multiomic, and spatial sequencing data, from raw-data processing and quality assessment through biological interpretation and communication of findings. 

Goals/Outcomes of the Research Project: A major focus of the role is translating complex sequencing data into biologically meaningful insights related to immune activation, inflammation, tissue microenvironments, disease mechanisms, treatment response, and potential biomarkers.

Technical Duties: (include any protocols) 

• Perform independent research and process, quality control integrate, and interpret high-dimensional omics data to characterize immune-cell populations, transcriptional states, chromatin accessibility, inflammatory pathways, and disease-associated signatures.
• Characterize the composition and functional state of immune populations to study transcriptional states, immune activation, exhaustion, regulation, cellular heterogeneity, and identify disease-associated immune signatures, inflammatory pathways and candidate biomarkers across patient cohorts and experimental conditions.
• Integrate molecular, spatial, clinical, and experimental data across tissues, disease states, and treatment groups to investigate immune mechanisms and tissue microenvironments.
• Collaborate with we-laboratory scientists, clinicians, immunologists, and pathologists on experimental design, assay troubleshooting, data interpretation, and translational research questions.
• Develop and maintain reproducible analytical workflows and generate, reports, and summaries for ongoing projects, manuscripts, and other collaborative studies.

7. Co-lead training seminars.

Qualifications:

• Ph.D. required
• Experience working in a research laboratory setting
• Experience analyzing high-dimensional genomic datasets in a biological, clinical, or translational research setting.
• Strong understanding of molecular biology and immunology.
• Ability to interpret genomic results using immune-cell markers, signaling pathways, transcriptional programs, and disease-specific biological context.
• Strong proficiency in R, python and related single-cell data structures, analytical frameworks and HPC.
• Knowledge of statistical methods used in genomic and high-dimensional biological data analysis.

This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. 

Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf. 

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