Scientist, Large Molecule Analytical (On-site)

The Large Molecule Analytical department of our Research & Development Division is seeking applicants for a Scientist position. The Scientist is a laboratory-based scientific role tasked with solving complex analytical problems at the interface of biology, chemistry, and lab informatics disciplines to enable development of Biologics drug substances and drug products.  The successful candidate must function well and be able to collaborate in a fast-paced, integrated, multidisciplinary team environment.  The qualified candidate will be responsible for development, qualification, implementation, troubleshooting and transfer of analytical methods for monoclonal proteins or other complex therapeutic proteins.  Applicants must have effective organizational, multi-tasking, oral/written communications skills, show scientific leadership, and a desire to conduct research and publish. Evidence of strong cross-functional collaboration in an academic or industrial setting is also preferred. 

• BA/BS in analytical chemistry/biochemistry or related field with a minimum of 3 years of experience in the Pharmaceutical Industry, or
• M.S. with a minimum of 0+ year relevant experience (with expected graduation no later than January 2027).

• Prior experience in a laboratory environment
• Ability to develop and apply basic principles and scientific concepts to execute work in a laboratory setting
• Execute routine experiments and data interpretation with appropriate technical guidance

• Ability to operate and troubleshoot analytical methods

• Understanding of the fundamentals in separations science
• Experience with UPLC/HPLC analysis of biologics (e.g., SEC, RP, IEX) and CE techniques or molecular biology (PCR, DNA extraction) and immunoassay (ELISA, gel electrophoresis) techniques
• Ability to work within overall project timelines to manage prioritization and execution of individual deliverables with appropriate supervision

• Demonstrated experience working within collaborative team environments

• Experience in authoring and reviewing internal technical reports, sections of regulatory filings (e.g., IND, BLA) and external scientific publications

• Past experience working as part of a project team  
• Strong knowledge of protein structure and degradation pathways
• Experience in analysis of various Biologic modalities (e.g., mAb, antibody-drug conjugate, fusion protein)
• Background in Analytical Methodologies and sound scientific understanding of Critical Quality Attributes/QbD/DOE principles
• Prior experience with Microsoft Office and other research applications (e.g., RLIMS, ELN, Empower)
• Experience in data analytics, programming, or laboratory automation

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Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is:

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.