Postdoctoral Scholar - Dermatology

The laboratory of Dr. Ryan Hobbs in the Penn State College of Medicine, Department of Dermatology, is seeking a full-time Postdoctoral Scholar to work on campus in Hershey, Pennsylvania.
Research in the Hobbs Laboratory focuses on understanding how epithelial cells sense and respond to cellular, environmental, and inflammatory stress. Using skin keratinocytes as a primary model system, the laboratory investigates the molecular mechanisms that regulate epithelial survival, differentiation, cell adhesion, tissue repair, and disease development. Current projects integrate advanced light microscopy, cell and molecular biology, functional genomics, and drug-discovery approaches to identify pathways that control keratinocyte stress responses and to evaluate potential therapeutic modifiers of epithelial dysfunction.
The successful applicant will lead research projects employing advanced fluorescence and live-cell microscopy techniques to investigate dynamic cellular and molecular processes in keratinocytes. The position will also involve the development and implementation of targeted and higher-throughput drug-discovery screening approaches, including assay optimization, compound testing, quantitative imaging, and validation of candidate therapeutic agents.
Applicants should possess pronounced expertise in keratinocyte biology and a strong foundation in cellular and molecular biology. Demonstrated experience with mammalian cell culture, fluorescence microscopy, quantitative image analysis, biochemical assays, and molecular biology techniques is strongly preferred. Experience with advanced light microscopy, automated imaging, drug or small-molecule screening, three-dimensional epithelial culture models, primary cell culture, or mouse skin biology is desirable.

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