Head of Medical Affairs

Remix launched with a vision to transform patients’ lives through modulation of RNA processing. Our breakthrough science enables the identification of small molecules that influence the expression of disease‑driving mRNAs and proteins. We focus on diseases of high unmet medical need and are committed to operating with scientific rigor and urgency. With a proprietary in‑house technology platform, we have rapidly generated multiple discovery programs advancing toward the clinic. Remix Therapeutics was recognized as one of BioSpace’s Best Places to Work in Boston 2025 and is backed by leading life sciences investors.

Remix is seeking a Head of Medical Affairs to provide medical affairs leadership for REM-422 and contribute to the development of future programs across the portfolio. REM-422 is an innovative investigational therapy targeting RNA splicing machinery, with adenoid cystic carcinoma (ACC), a rare salivary gland cancer, as its first clinical indication. With no approved therapy for ACC, this is an opportunity to help shape the medical and treatment landscape for patients with a rare cancer while playing a key role in advancing a novel therapeutic approach. 

Reporting directly to the Chief Medical Officer and based at our Watertown, MA headquarters, this individual will play a central role in disease education, scientific leadership, external engagement, evidence generation and trial execution, and interpretation of emerging clinical data. This is the first medical affairs hire at Remix. You will define what the function is, hire the people who follow you, and grow the organization as REM-422 moves toward approval and launch.  You will also be the external scientific voice of the company, personally engaged in the field with KOLs and advocacy leaders. The role is global in scope; however, the United States is the initial focus and the first launch market. 

• Advanced life science degree required. MD or equivalent medical degree preferred; PhD or PharmD considered. 

• 10+ years in medical affairs and prior leadership of the function. 

• Oncology experience is required. Solid tumors strongly preferred; head and neck or salivary gland is a distinct advantage. 

• Built a Medical Affairs function from an early state rather than only running an established one. 

• Launch experience preferred, ideally with a first in class or first in disease product where the treatment pathway had to be established. 

• Existing relationships across oncology academic institutions.  

• Global perspective preferred, including working knowledge of the European medical affairs and regulatory environment or experience supporting ex-US capability. 

• Excellent written and verbal communication skills, including experience authoring or reviewing scientific and medical content for external audiences. 

• Demonstrated ability to operate effectively in a highly collaborative, cross-functional, and fast-paced biotechnology environment. 

$293,000 - $415,000 USD 

This range reflects the expected base salary for this position, plus bonus, equity, and benefits as applicable.  Actual salaries may vary based on factors, such as skill, experience, and qualification for the role.