Nucleic Acids Specialist, ATMF

·  University degree in Molecular Biology, Biochemistry, Biotechnology, Bioengineering, Microbiology, or a closely related discipline plus a minimum of four years of related laboratory experience, or an equivalent combination of education and experience. Relevant graduate training or an M.Sc. is an asset.

·  Demonstrated advanced knowledge of molecular biology and nucleic acid biochemistry, with the ability to independently design, evaluate, and troubleshoot DNA constructs and RNA production strategies.

·  Demonstrated hands-on experience with plasmid design, molecular cloning, sequence analysis, and nucleic acid purification and characterization.

·  Demonstrated hands-on experience with IVT and production, purification, or characterization of mRNA or other RNA products.

·  Strong understanding of plasmid architecture and design considerations for IVT and/or viral vector production.

·  Experience optimizing and scaling enzymatic reactions or nucleic acid manufacturing processes.

·  Experience with analytical methods used to assess DNA and RNA identity, purity, concentration, integrity, and process-related impurities.

·  Experience with bacterial fermentation, bioreactor-based plasmid production, or scale-up of plasmid DNA manufacturing is a strong asset.

·  Experience with viral vector plasmid design or production is an asset.

·  Experience with LNP formulation, microfluidic mixing, RNA encapsulation, or RNA-LNP characterization is a strong asset; candidates with combined RNA and LNP experience are particularly desirable.

·  Experience working in a GMP/GLP or other regulated biomanufacturing environment is an asset.

·  Experience applying Quality by Design (QbD), design of experiments (DoE), or systematic process-development approaches is an asset.

·  Demonstrated ability to independently plan experiments, analyze complex data, troubleshoot unexpected results, and make scientifically justified recommendations.

·  Exceptional attention to detail, particularly in sequence design, calculations, experimental preparation, sample tracking, and technical documentation.

·  Strong organizational and technical writing skills, including preparation of SOPs, protocols, development reports, and technology-transfer documentation.

·  Ability to critically evaluate scientific literature, vendor information, and emerging technologies and determine their applicability to process-development activities.

·  Comfortable working across multidisciplinary teams and communicating technical information clearly to colleagues with different areas of expertise.

·  Demonstrated ability to train and provide technical guidance to junior staff and trainees.

·  Contributes to a collaborative, respectful, and inclusive laboratory environment.

UBC hires on the basis of merit and is strongly committed to equity and diversity within its community. We especially welcome applications from visible minority group members, women, Indigenous persons, persons with disabilities, persons of minority sexual orientations and gender identities, and others with the skills and knowledge to productively engage with diverse communities.