Director (Principal Scientist) - Precision Medicine - Outcomes Research

This position resides within our company Value and Implementation (V&I) Oncology organization, which leads the execution of value evidence plan and delivery of strategic real-world evidence (RWE) capabilities to inform healthcare decision making.  Under the guidance of a senior leader, the Principal Scientist will provide US and ex-US outcomes research support for Oncology programs focusing on Precision Medicine. 

• To provide leadership and consultation on evidence generation methods for translational oncology/molecular epidemiology studies to support access, value demonstration, and medical implementation.  Precision Medicine studies the candidate will lead include those on biomarkers with approved diagnostics across multiple tumors, studies involving tissue processing or acquisition, and studies on emerging biomarkers without approved diagnostics.
• To provide subject matter expertise in Outcomes research and precision medicine to internal and external stakeholders, including precision medicine integrated value and implementation team and related functions.
• To design and execute observational and real-world studies in support of access, value demonstration, and medical implementation.
• To inform and contribute to the value evidence plan and associated studies which demonstrate clinical, economic, and patient-centered value.
• To support the implementation of the RWE capability maturity model for global excellence in RWE generation, in partnership with local RWE experts and stakeholders.
• To communicate findings from the research to relevant internal and external audiences, including supporting the development of communication resources.

• To collaborate with internal stakeholders to ensure research priorities and plans are aligned
• To communicate with relevant external audiences including health care providers, health systems, HTAs, patient organizations, and others
• To design and execute outcome research studies, in collaboration with scientific leaders, patient organizations, academic medical centers, health systems, research organizations, database holders, and others.
• To prepare outcome research protocols, statistical analysis plans, and clinical study reports.
• To communicate findings at scientific conferences, publications, dossiers, and by other means.
• To maintain awareness of scientific developments in the field
• Expertise in translational oncology/molecular epidemiology, observational study best practices, fitness-for-use, real world evidence frameworks, and global guidelines on the conduct of observational research.

• Doctoral degree in relevant discipline (health services research, outcomes research, epidemiology, public health, health economics, pharmacoeconomics, pharmacy administration)

• Expertise in Real-world evidence generation, advanced biostatistics and computational biology.
• Prior experience in digital pathology related analytics.
• Laboratory experience to understand how tissue is processed, including sample logistics, biobanking, pathology, and QA/QC considerations.
• Expertise in diagnostic test modalities (e.g., IHC, ISH, PCR, NGS, digital pathology, multiplex), Assay sensitivity/specificity.
• A track record of scientific presentations and publications.
• Four or more years of experience with a post degree.

• Experience in Oncology related outcome research and/or epidemiology.

Current Employees apply HERE

Current Contingent Workers apply HERE

Rahway, New Jersey

Upper Gwynedd, Pennsylvania

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

The primary location for this posting is:

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is:

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.