Protein ML Senior Principal Data Scientist

• Develop state-of-the-art protein property prediction models with a focus on immunogenicity, stability, and manufacturability to support vaccine design.
• Leverage and refine language-based foundational protein representations to accelerate the identification and optimization of vaccine candidates.
• Analyze complex relationships between protein sequences, structures, and functional data to uncover generalizable representations applicable across vaccine programs.
• Collaborate with structural biology, protein design, and bench lab teams to shape the strategy for protein modeling and to iteratively improve model quality
• Maintain the modeling codebase according to best coding practices, ensuring results are robust, reproducible, and well-documented.
• Mentor and upskill colleagues on the latest advances in protein modeling tools and techniques, fostering a culture of continuous learning and scientific rigor.
• Communicate scientific findings clearly and compellingly to a broad range of internal and external stakeholders, adapting the level of detail to each audience.

• PhD degree in Computational Biology, Data Science, Applied Mathematics, Biophysics or a closely related field

• 2 + years of industry or academic setting experience.

• Exceptional track record in computational biology, encompassing protein language models, biophysics, and the development of AI-based predictive models; prior experience with immunogenicity predictors is a plus.
• Advanced proficiency in Python, R, and SQL, with hands-on experience in PyTorch and AI-based structural modeling tools such as AlphaFold, OpenFold, and Boltz
• Deep knowledge of protein representation models such as ESM
• Familiarity with molecular dynamics, next-generation sequencing analysis, and deep mutational scanning is an advantage.
• Familiarity with agentic tools such as Claude Code for automated software engineering strongly preferred.
• Demonstrated ability to communicate fluently — in writing and in person — across computational and bench lab teams, adapting messaging to diverse audiences including senior leadership
• Proven ability to mentor junior colleagues and lead collaboratively in the area of protein modeling.
• Strong problem-solving, communication, and collaboration skills across multidisciplinary teams.

• Fluent English required.

• Bring the miracles of science to life alongside a supportive, future focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
• Work at the forefront of AI-driven research, smart manufacturing, and groundbreaking mRNA platforms that are redefining the future of immunology.
• Help protect half a billion people every year, contributing to one of the largest global vaccination efforts in healthcare.
• Develop your career with access to mentoring, international mobility programs, and opportunities to grow across four continents.

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

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US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

North America Applicants Only

The salary range for this position is:

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.