Scientific Fellow (Director), Immunology

Create and update research operating plans, including resource planning, budget management, risk assessment and contingency planning for your programs 

Secure cross-functional alignment and organizational support for program plans 

Lead multidisciplinary program teams and be accountable for meeting program goals, milestones and timelines 

Define stage-gate success criteria and timelines for your programs, recommend resource allocation and go/no-go decisions to leadership  

Manage CRO partnerships across all biology activities in support of your programs, including study design, execution, data quality and delivery to project teams 

Shape the validation of targets and the scientific strategy for the immunology portfolio, advising leadership on opportunities and trade-offs  

Engage key opinion leaders and external experts to pressure-test program hypotheses, align priorities with leadership and inform business and partnering decisions 

Present program progress to senior leadership, and represent programs to prospective partners and at scientific conferences 

Design and oversee hit finding campaigns (e.g., HTS and DEL), including hit triage and confirmation 

Build and transfer fit-for-purpose assay cascades (biochemical, biophysical, cellular and whole blood) that support hit triage, SAR, target engagement and mechanism of action, to team members in-house and at CROs 

Build new in-house capabilities and technologies (e.g., assay platforms, human-cell and whole-blood systems) that serve multiple programs and keep PsiThera at the leading edge 

Evaluate emerging technologies, CROs and academic or industry collaborations 

Mentor scientists across the organization and constructively challenge scientific thinking 

PhD in Immunology, Molecular and Cellular Biology, or a related field with 12+ years of biotech or pharma drug discovery experience, or an MS with 16+ years of equivalent experience 

Track record of advancing small molecules from hit identification to DC selection as project team leader or lead biologist 

Hands-on experience in hit finding, including screening assay development, HTS or DEL campaigns, and hit triage and confirmation 

Prior people management experience and demonstrated leadership of cross-functional project teams or workstreams 

Hands-on expertise with primary human immune cells and whole blood, and in building assay cascades (biochemical, biophysical, cellular) for screening, SAR and mechanism-of-action studies 

Broad knowledge of in vitro and in vivo models of inflammation and autoimmunity, with experience designing and interpreting in vivo pharmacology and PK/PD studies 

Experience managing CRO collaborations 

Scientific achievement shown through peer-reviewed publications and/or patents 

Strong scientific rigor in generating, analyzing and presenting data to drive program decisions 

Excellent written and verbal communication skills with scientific, executive and partner audiences 

Experience across multiple target classes and therapeutic areas 

Experience working with clinical teams on translational research or biomarker strategy