Senior Software Engineer, Site Reliability

Do you have what it takes to be a Freenomer? A “Freenomer” is a determined, mission-driven, results-oriented employee fueled by the opportunity to change the landscape of cancer and make a positive impact on patients’ lives. Freenomers bring their diverse experience, expertise, and personal perspective to solve problems and push to achieve what’s possible, one breakthrough at a time.

Our Site Reliability Engineering (SRE) team is a new and critical function at Freenome. As a founding member of the team, you’ll help define the culture and build the systems that keep our regulated, cloud-based production environments reliable as we transition from research to commercial operations. This is an opportunity to do meaningful engineering work that will directly save lives. 

We value:

• Reliability as a product feature
  
• Continual improvement and learning
  
• Automate all the things!
  
• Technical simplicity and clarity
  
• Blameless postmortems and transparent communication 

• →Define and implement observability practices (metrics, traces, dashboards, logs, alerts) for production systems.
• →Partner with product, engineering, and lab teams to develop and maintain incident response playbooks and escalation procedures.
• →Partner with engineering teams to define SLIs/SLOs and establish error budgets.
• →Participate in on-call rotation for production systems, champion a focus on automation and self-healing.
• →Contribute to production deployment and change-management processes that meet FDA and compliance requirements.
• →Automate operational tasks, reducing manual intervention.
• →Contribute to production systems and designs with the goal of improving reliability.
• →Use Infrastructure as Code (IaC) to manage and deploy team owned infrastructure and subsystems
• →Help build out the SRE practice.
• →Work closely with engineering, product, and lab teams to understand service reliability needs.
• →Partner with TPMs, RA/QA, and compliance stakeholders to align operational practices with regulatory requirements.
• →Participate in cross-functional incident reviews and postmortems.
• →Share knowledge and document operational standards for consistency and onboarding.
• →Design and run fire drills / tabletop exercises as well as disaster recovery exercises
• →Independently drive reliability improvements in scoped systems or services.
• →Provide mentorship to peers on observability, incident management, and operational best practices.
• →Help build and evolve Freenome’s reliability practices and contribute to team strategy discussions.

• Bachelor’s degree in Computer Science, Engineering, or equivalent experience.
• 5+ years in software engineering or Infra/DevOps/SRE roles (Python or Go preferred).
• Experience deploying cloud infrastructure via automation (e.g. Terraform, Pulumi, Bicep/ARM, etc.)
• Hands-on experience operating production workloads in cloud environments.
• Familiarity with Kubernetes (AKS, GKE, or EKS).
• Strong troubleshooting and root-cause analysis skills in distributed systems.
• Experience with observability platforms (e.g., DataDog, Prometheus/Grafana, OpenTelemetry).
• Ability to define and implement metrics, dashboards, and alerting.
• Demonstrated ability to work autonomously and own technical outcomes.
• Strong understanding of cloud Infrastructure and Networking architectures and automation.

• Experience supporting regulated environments (healthcare, biotech, financial).
• Familiarity with compliance-driven change management and release processes (FDA, HIPAA).
• Experience with incident management platforms (e.g., Incident.io, ServiceNow, Opsgenie, Pagerduty).
• Knowledge of CI/CD deployment strategies and change automation.
• Experience with both GCP and Azure cloud platforms.
• Interest in mentorship and system reliability practices at scale.