340B Implementation Quality Assurance Analyst

A 340B Implementation Quality Assurance (QA) Analyst ensures that a covered entity’s 340B Drug Discount Program is implemented, operated, and maintained in full compliance with HRSA regulations, internal policies, and program integrity standards. This role blends compliance oversight, process implementation, and quality assurance to ensure the 340B program delivers intended savings and meets all regulatory and internal standards. The role is to oversee the implementation, monitoring, and compliance of the 340B program, including audit activities, process validation, and risk mitigation to prevent duplicate discounts, diversion, and eligibility errors.

• Conduct regular internal audits of 340B Office of Pharmacy Affairs Information System (OPAIS) records, retail pharmacies (entity-owned and contract), and Medicaid claims to ensure adherence to HRSA requirements
• Validate patient, provider, and drug eligibility for all 340B transactions
• Review and interpret state Medicaid billing requirements and compare against claims data
• Participate in external 340B program audits and prepare data/documentation for review

• Develop and maintain 340B policies, procedures, and workflows for purchasing, referral capture, and contract pharmacy management
• Administer referral prescription capture processes and ensure documentation supports eligibility
• Monitor contract pharmacy portals for missed claims, investigate denials/reversals, and coordinate remediation
• Configure and maintain eligible provider tables, location/site mapping, and excluded NDCs/drugs in compliance with internal and HRSA standards

• Identify compliance risks, prevent diversion, and ensure consistent processes across all points of service
• Develop training programs (e.g., 340B University OnDemand) for staff on 340B procedures and inventory management
• Monitor regulatory updates and communicate implications to program operations

• Generate program utilization, savings, and exception reports for management and stakeholders
• Collaborate with IT, audit, accounting, and pharmacy teams to share data, improve efficiency, and ensure compliance
• Provide data, reports, and insights to support other business units

• High school diploma/GED; pharmacy or healthcare-related degree preferred
• 1–3+ years in 340B program work; prior QA, compliance, or pharmacy operations experience preferred

· In-depth knowledge of HRSA 340B regulations and program mechanics

· Proficiency in Excel, SQL, data analysis, and 340B software

· Strong analytical, organizational, and communication skills

· Ability to work independently and meet deadlines

• Implementation quality scores.
• Number of post-go-live defects identified.
• Defect resolution turnaround times.
• First-pass testing success rates.
• Accuracy of implementation validations.
• Compliance audit findings.
• Client implementation satisfaction scores.
• On-time project delivery support.
• Reduction in implementation rework.
• Effectiveness of risk identification and mitigation.